Clinical Research

"My role this year has expanded to include both clinical and health services research. There are endless opportunities to capitalize on the inherent, bidirectional synergies in these arenas and I look forward to collaborating with my clinical and health services research colleagues to take full advantage of them." - Rodica Pop-Busui, MD, PhDLearn more about Dr. Pop-Busui.

Clinical & Health Services Research Connection

Internal Medicine has a sizable and accomplished history in health services research. Researchers from our department make up the largest group within U-M’s Institute for Healthcare Policy & Innovation (IHPI). Because our health services research footprint is so vast, we have the perfect opportunity to stimulate the development of clinical research projects that address pressing topics already being investigated by our IHPI colleagues, from healthy aging to the opioid epidemic. As our clinical trialists identify effective interventions, our outcomes researchers can examine them in clinical practice. And if an intervention falls short in practice, our trialists can compare alternatives. With our health services and clinical researchers working together, we can make quicker advancements to improve patient care.

The Clinical Trials Academy, offered jointly by the Department of Internal Medicine and the Medical School, is a hands-on training program in clinical research and clinical trial design. Learn more.

Anna Mathew, MD is our latest Clinical Research Spotlight. She is active in translational research studying chronic kidney disease, diabetic kidney disease, and cardiovascular disease in chronic kidney disease using metabolomics and proteomics approaches. Learn more.

Funded by the National Institutes of Health, Michigan Medicine and five other U.S. research institutions launch the first-ever multicenter network to study diabetic foot ulcers. Learn more.

Michigan Medicine launch two new clinics aimed at treating and studying COVID-19's long-term outcomes in vulnerable adult and pediatric populations. Read more.

The Michigan Medicine/Peking University Health Science Center (PKUHSC) Joint Institute for Translational and Clinical Research funded 12 projects for 2019, 4 of which were co-led by Department of Internal Medicine researchers. Learn more.

Belzutifan Offers Hope for Patients with Von Hippel-Lindau Disease

Tobias Else, MD and colleagues find that belzutifan may help patients with rare, hereditary cancer syndromes avoid surgeries by shrinking tumors via a daily oral dose. Read more.

Diabetic Neuropathy Tied to Urological Complications in Men with Type 1 Diabetes: Study

Rodica Busui, MD, PhD and William Herman, MD, MPH find that in long-standing type 1 diabetes, diabetic peripheral neuropathy is associated with the later development of urological complications in men. Read more.

Patients with Rare Scleroderma Have Deadlier Organ Damage, Despite Getting Standard Treatment

Sara Jaafar, MD; Dinesh Khanna, MD, MSc; and team find that patients with a rare form of scleroderma have a greater chance of dying from related kidney, heart, and lung problems, despite taking medications used to treat most patients with the disease. Read more.

Treatment Enhances Anti-Leukemia Effect of Bone Marrow Transplant, Reduces Recurrence, Study Finds

John Magenau, MD, Pavan Reddy, MD, and team identify a drug that, when given along with a bone marrow transplant, drops the risk of leukemia recurring by 20% among high-risk patients. Read more.