New State-of-the-Art Review Published in The British Medical Journal

Antiphospholipid Syndrome: Advances in Diagnosis, Pathogenesis, and Management

Authors: Jason S. Knight, D. Ware Branch, Thomas L. Ortel

Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19

Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19, published in Science Translational Medicine in November 2020, has been featured in over 110 news outlets.

Recent Publications

Antiphospholipid Syndrome Management: a 2023 Update and Practical Algorithm-Based Approach
Ambati, Amala; Knight, Jason S.; Zuo, Yu. Current Opinion in Rheumatology. March 3, 2023

Anti-NET Antibodies in Antiphospholipid Antibody-Positive Patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository
Yu Zuo MD, Sherwin Navaz BS, Alex Tsodikov PhD, Katarina Kmetova MS, Lyndsay Kluge, Amala Ambati MD, Claire K. Hoy BS, Srilakshmi Yalavarthi MS, Danieli de Andrade MD, PhD, Maria G. Tektonidou MD, PhD, Savino Sciascia MD, PhD, Vittorio Pengo MD, Guillermo Ruiz-Irastorza MD, H. Michael Belmont MD, Maria Gerosa MD, PhD, Paul R. Fortin MD, Guilherme Ramires de Jesus MD, D. Ware Branch MD, Laura Andreoli MD, PhD, Esther Rodriguez-Almaraz MD, Michelle Petri MD, Ricard Cervera MD, Rohan Willis MD, David R. Karp MD, PhD, Quan-Zhen Li MD, PhD, Hannah Cohen MD, Maria Laura Bertolaccini PhD, Doruk Erkan MD, Jason S. Knight MD, PhD, on behalf of APS ACTION. Arthritis & Rheumatology. March 2, 2023

An Update on Inflammation in Antiphospholipid Syndrome
Ambati, Amala; Zuo, Yu; Knight, Jason S. Current Opinion in Rheumatology. March 2023

Antiphospholipid Syndrome: Advances in Diagnosis, Pathogenesis, and Management
Jason S Knight, D Ware Branch, Thomas L Ortel. The British Medical Journal. February 27, 2023 

Predictors and Interrelationship of Patient-Reported Outcomes in Antiphospholipid Syndrome: A Cross-Sectional Study
Weiner JK, Smith T, Hoy CK, Sarosh C, Madison JA, Ambati A, Tambralli A, Peters N, Packel C, Gockman K, Zuo Y, Briceño EM, Nagaraja V, Knight JS. ACR Open Rheumatology. December 2, 2022

Pediatric Antiphospholipid Syndrome: Clinical Features and Therapeutic Interventions in a Single Center Retrospective Case Series
Madison JA, Gockman K, Hoy C, Tambralli A, Zuo Y, Knight JS. Pediatric Rheumatology. February 23, 2022

Endothelial Cell-Activating Antibodies in COVID-19
Shi H, Zuo Y, Navaz S, Harbaugh A, Hoy CK, Gandhi AA, Sule G, Yalavarthi S, Gockman K, Madison JA, Wang J, Zuo M, Shi Y, Maile MD, Knight JS, Kanthi Y. Arthritis & Rheumatology. February 17, 2022

Mechanisms of Immunothrombosis and Vasculopathy in Antiphospholipid Syndrome
Knight JS, Kanthi Y. Seminars in Immunopathology. February 4, 2022

Defibrotide Inhibits Antiphospholipid Antibody-Mediated NET Formation and Venous Thrombosis
Ali RA, Estes SK, Gandhi AA, Yalavarthi S, Hoy CK, Shi H, Zuo Y, Erkan D, Knight JS. Arthritis & Rheumatology. November 1, 2021

The Intersection of COVID-19 and Autoimmunity
Knight JS, Caricchio R, Casanova JL, Combes AJ, Diamond B, Fox SE, Hanauer DA, James JA, Kanthi Y, Ladd V, Mehta P, Ring AM, Sanz I, Selmi C, Tracy RP, Utz PJ, Wagner CA, Wang JY, McCune WJ. The Journal of Clinical Investigation. October 28, 2021

Endothelium-Protective, Histone-Neutralizing properties of the Polyanionic Agent Defibrotide
Shi H, Gandhi AA, Smith SA, Wang Q, Chiang D, Yalavarthi S, Ali RA, Liu C, Sule G, Tsou PS, Zuo Y, Kanthi Y, Farkash EA, Lin JD, Morrissey JH, Knight JS. JCI Insight. September 8, 2021

Autoantibodies Stabilize Neutrophil Extracellular Traps in COVID-19
Yu Zuo, Srilakshmi Yalavarthi, Sherwin A. Navaz, Claire K. Hoy, Alyssa Harbaugh, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Hui Shi, Yogendra Kanthi, and Jason S. Knight. JCI Insight. June 24, 2021

Endoplasmic Reticulum Stress Sensor IRE1α Propels Neutrophil Hyperactivity in Lupus
Gautam Sule, Basel H. Abuaita, Paul A. Steffes, Andrew T. Fernandes, Shanea K. Estes, Craig J. Dobry, Deepika Pandian, Johann E. Gudjonsson, J. Michelle Kahlenberg, Mary X. O'Riordan, Jason S. Knight. The Journal of Clinical Investigation. February 9, 2021

Anti-Neutrophil Properties of Natural Gingerols in Models of Lupus
Ramadan A. Ali, Alex A. Gandhi, Lipeng Dai, Julia K. Weiner, Shanea K. Estes, Srilakshmi Yalavarthi, Kelsey Gockman, Duxin Sun, Jason S. Knight. JCI Insight. December 29, 2020

Neutrophil Extracellular Traps and Thrombosis in COVID-19
Zuo Y, Zuo M, Yalavarthi S, Gockman K, Madison JA, Shi H, Woodard W, Lezak SP, Lugogo NL, Knight JS, Kanthi Y. Journal of Thrombosis and Thrombolysis. November 5, 2020

Neutrophil Calprotectin Identifies Severe Pulmonary Disease in COVID-19
Shi H, Zuo Y, Yalavarthi S, Gockman K, Zuo M, Madison JA, Blair C, Woodward W, Lezak SP, Lugogo NL, Woods RJ, Lood C, Knight JS, Kanthi Y. Journal of Leukocyte Biology. September 1, 2020

Anti-NET Antibodies and Impaired NET Degradation in Antiphospholipid Syndrome
Zuo Y, Yalavarthi S, Gockman K, Madison JA, Gudjonsson JE, Kahlenberg JM, McCune WJ, Bockenstedt PL, Karp DR, Knight JS. Arthritis & Rheumatology. July 30, 2020

New (Re)Purpose for an Old Drug: Purinergic Modulation May Extinguish the COVID-19 Thromboinflammatory Firestorm
Kanthi Y, Knight JS, Zuo Y, Pinsky DJ. JCI Insight. June 12, 2020

Neutrophil Extracellular Traps in COVID-19
Yu Zuo, Srilakshmi Yalavarthi, Hui Shi, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Christopher N. Blair, Andrew Weber, Betsy J. Barnes, Mikala Egeblad, Robert J. Woods, Yogendra Kanthi, and Jason S. Knight. JCI Insight. April 24, 2020

Increased Adhesive Potential of Antiphospholipid Syndrome Neutrophils Mediated by Beta‐2 Integrin Mac‐1
Sule G, Kelley WJ, Gockman K, Yalavarthi S, Vreede AP, Banka AL, Bockenstedt PL, Eniola-Adefeso O, Knight JS. Arthritis & Rheumatology. July 28, 2019