August 2, 2013

Jeffrey Kidd is key team leader of U-M, Stanford, and Stony Brook research team showing most recent male & female common ancestors lived around the same time and is published in the journal Science.

"More than 7 billion people live on this planet – members of a single species that originated in one place and migrated all over the Earth over tens of thousands of years.

But even though we all trace our family lineage to a few common ancestors, scientists still don’t know exactly when and how those few ancestors started to give rise to the incredible diversity of today’s population.

A brand-new finding, made using advanced analysis of DNA from all over the world, sheds new light on this mystery. By studying the DNA sequence of Y chromosomes of men from many different populations, scientists have determined that their male most recent common ancestor (MRCA) lived sometime between 120,000 and 156,000 years ago.

It’s the first time the human ancestry has been traced back through the male line by sequencing the DNA of many entire Y chromosomes.

And, it agrees reasonably well with previous findings about our female most recent common ancestor, made by studying DNA carried down through the human race’s female line. Such studies used DNA from mitochrondria -- structures inside cells – and placed that time of the most recent common ancestor between 99,000 and 148,000 years ago. That agreement makes the new finding especially significant:

The research was done by a team of scientists from Stanford University, the University of Michigan Medical School, Stony Brook University, and their colleagues, and is published in the journal Science.

The team hopes their work will lead to further research on Y chromosomes as vehicles for studying human history – and tracing male lineages back to the common “Adam” ancestors.

Jeffrey Kidd, Ph.D., an assistant professor in U-M's departments of Human Genetics and Computational Medicine & Bioinformatics who worked on the new study, notes that only recently has it become possible to sequence Y chromosomes, because of technical limitations of previous approaches.

The new paper details how the team was able to make reliable measurements of the sequence variation along the Y chromosome – which is handed down only from father to son without exchanging, or recombining, genetic material with other chromosomes.

Kidd notes that this initial paper on Y chromosome sequence diversity provides important first evidence that the male most recent common ancestor did not live more recently than the female most recent common ancestor.

“We’re interested in understanding the historical relationships between many different human populations, and the migration patterns that have led to the peopling of the world,” he says. “We hope that others will make use of this approach and sequence additional chromosomes of interest that are related to the peopling of specific places.”

The study involved Y chromosomes obtained through the Human Genome Diversity Project, and from other sources. It included chromosomes from 69 men in several populations in sub-Saharan Africa, and from Siberia, Cambodia, Pakistan, Algeria and Mexico.

The great migrations of our ancestors out of Africa, across Asia and Europe and into the Americas all helped shape today’s populations – as did more recent forces related to colonialism and ever-growing global mobility.

Genetic studies such as this one may help anthropologists understand those migrations – and their timing – even better by giving them a genetic “clock” to use when studying today’s humans, or potentially DNA extracted from ancient bones. It may also help scientists understand the great genetic diversity seen across Africa, and the evolution process that led to modern humans.

The reconciliation of the timing of ancestors some might call “Adam” and “Eve”, however, may be this study’s most important immediate implication.

“This has been a conundrum in human genetics for a long time,” said Carlos D. Bustamante, Ph.D., a professor of genetics at Stanford and senior author of the study. “Previous research has indicated that the male MRCA lived much more recently than the female MRCA. But now our research shows that there’s no discrepancy. In fact, if anything, the Y chromosome may be a bit older.”

In addition to Kidd and Bustamante, the research team includes U-M’s Elzbieta Sliwerska, Stanford’s G. David Poznik, Brenna M. Henn, Muh-Ching Yee, Ghia M. Euskirchen, Alice A. Lin, Michael Snyder, and Peter A. Underhill, and Lluis Quintana-Murci from Institut Pasteur in Paris.

Reference: Science 2 August 2013: Vol. 341 no. 6145 pp. 562-565 DOI: 10.1126/science.1237619

Funding: National Library of Medicine LM-07033, National Science Foundation DGE-1147470; National Institutes of Health 3R01HG003229 and DP5OD009154; Institut Pasteur, CNRS MIE, Foundation Simone et Cino del Duca."

Jeff Kidd, Ph.D.

Jeff Kidd, Ph.D.

Professor of Human Genetics
Professor of Computational Medicine and Bioinformatics