Rashi Singhal, PhD

Yatrik Shah Lab

7703 Med Sci II
Ann Arbor MI 48109-5622


Areas of Interest

My research is focused on studying metabolic and immune regulation of tumor hypoxia . I am particularly interested in assessing the complex tumor microenvironment and its impact on anti-tumor immunity.

Honors & Awards

  • October 2021 - APS Postdoctoral Fellowship Award, American Physiological Society
  • April 2021 - Early-stage Postdoctoral Award, excellence in research, University of Michigan
  • November 2018 - Best Prize Award, Poster Competition, Immunocon, Indian Immunology Society Conference, THSTI, Faridabad, India
  • September 2018 - Best Prize Award, Poster Competition at RCB OPEN DAY- Outreach program under India International Science Festival
  • July 2018 - Reach the World travel Grant, (ISTH-SSC) meeting at Dublin, Ireland
  • February 2018 - Winner Prize, Science Communication competition, Science Day, RCB, Faridabad, India
  • August 2017 - Best Poster award, Cardiovascular Research Convergence, THSTI, Faridabad,
  • August 2017 - Torrent Young Investigator Award” for Oral presentation, Cardiovascular Research Convergence, THSTI, Faridabad, India
  • January 2016 - Best Poster Presentation Award, 3rd AIST International Imaging WS Tsukuba, Japan
  • 2013 Qualified CSIR National Eligibility Test holding 27th Rank
  • 2011 Qualified Graduate Aptitude Test Engineering (GATE) in Biotechnology with 97.35 percentile
  • 2012 - 2018 Scholarship, Department of biotechnology, Govt. of India
  • 2009 - 2011 Scholarship, National Merit Scholarship Program for Master of Science


PhD, Biotechnology, Regional Centre for Biotechnology-Faridabad India

Published Articles or Reviews

  1. Bell HN, Rebernick R, Joshua G, Singhal R, Kuljanin M, Kerk SA, Huang W, Das NK, Arden A, Solanki S, Miller S1, Todd P, Fearon ER, Lyssiotis CA, Gygi SP, Mancias JD, Shah YM (2022). Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance. Cancer Cell. (PMC8847337) 
  2. Singhal R, Mitta SR, DasNK, Kerk SA, Sajjakulnukit P, SolankiS, AndrenA, Kumar R, Olive KP,BanerjeeR, Lyssiotis CA, ShahYM. (2021) HIF-2a activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron. J Clin Invest. (PMC8203462) 
  3. Devenport SN, Singhal R, Taranto JG, Kerk SA, Goyert J, Chen B, Wilson KO, Greenson JK, Chen YE, Soleimanpour SA, Reddy P, Lyssiotis CA, Shah YM. (2021) Colorectal cancer cells utilize mitophagy to maintain cell proliferation under nutrient stress. JCI insight. (PMC8328084) 
  4. Schwartz AJ, Goyert JW, Solanki S, Kerk SA, Chen B, Castillo C, Hsu PP, Do BT, Singhal R, Dame MK, Lee HJ, Spence JR, Littleton SL, Heiden MGV, Lyssiotis CA, Xue X, Shah YM. (2021) Colorectal cancer requires ectopic hepcidin and sequesters iron to sustain nucleotide metabolism. Nature metabolism. (PMC8316354) 
  5. Singhal R, Shah YM. (2020) Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine. Journal of Biological Chemistry. jbc-REV120. (PMC7383395) 
  6. Singhal R, Rathore DK, Bhakuni T, Seth T and Guchhait P. (2019) Absence of non- classical monocytes in haemolytic patients: free Hb and NO mediated mechanisms. J Immunol Res. (PMC6458887) 
  7. Bhakuni T, Singhal R, Annarapu G, Sharma A, Mahapatra M, Saxena R, Guchhait P. (2019) Unique case of autoantibody mediated inactivation of ADAMTS13 in an Indian TTP patient. Blood cells, Molecules and Diseases. 77: 29-33 (PMID: 30953939) 
  8. Singhal R,Chawla S, Batra H, Gupta S, Ojha A, Rathore DK, Seth T and Guchhait P. (2018). Engulfment of Hb-activated platelets differentiates monocytes into pro-inflammatory macrophages in PNH patients.Eur. J. Immunol.doi: 10.1002/eji.201747449. (PMID: 29677388) 
  9. Singhal R, Chawla S, Rathore DK, Bhasym A, Annarapu GK, Sharma V, Seth T, and Guchhait P. (2017) Development of pro-inflammatory phenotype in monocytes after engulfing Hb-activated platelets in hemolytic disorders. Clin. Immunol. 175: 133-142. (PMID: 28039017) 
  10. Ojha A, Nandi D, Batra H, Singhal R, Annarapu GK, Bhattacharyya S, Seth T, Dar L, Medigeshi GR, Vrati S, Vikram NK, and Guchhait P. (2017) Platelet activation determines the severity of thrombocytopenia in dengue infection. Sci. Rep. 7:41697. doi: 10.1038/srep41697 (PMC5282509) 
  11. Annarapu GK*, Singhal R*, Gupta A, Chawla S, Batra H, Seth T, Guchhait P. (2016) HbS binding to GP1bα activates platelets in sickle cell disease. Plos One11(12): e0167899. (* Equal first author) (PMC5148012)
  12. Annarapu GK*, Singhal R*, Peng Y, Guchhait P. (2016) Inhibition of Hb binding to GP1bα abrogates Hb-mediated thrombus formation on immobilized VWF and collagen under physiological shear stress. Plos One, 11(4): e0154276. (* Equal first author) (PMC4841505) 
  13. Singhal R,Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, SethT, Guchhait P. (2015) Hemoglobin interaction with GP1bα induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Hematologic, 100: 1526-33. (PMC4666328)

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