Associate Professor, Molecular & Integrative Physiology
Associate Professor, Internal Medicine
Dr. Yin is Assistant Professor of Molecular & Integrative Physiology. Dr. Yin’s lab investigates the functional link between insulin signaling and molecular clock in liver and its potential role in insulin resistance. Our initial results suggest that insulin signaling is tightly associated with circadian clock in liver cells, suggesting a functional crosstalk between these two pathways. We want to explore this finding using both cell culture and animal model. We have generated adenovirus for expressing or knocking down the core clock proteins and those reagents will be used to manipulate liver specific clock using tail-vein injection approach and then study insulin signaling and insulin function. The experimental approaches include RNA extractin, QPCR, protein isolation, immunoblotting as well as immunoprecipitation.