October 27, 2023

Michigan Medicine Health Lab Features Groundbreaking ALS Research

"Drawing a tube of blood could assess ALS risk from environmental toxin exposure," covers new research by Goutman et al. that was published in the Journal of Neurology, Neurosurgery and Psychiatry.

Health Lab 

Drawing a tube of blood could assess ALS risk from environmental toxin exposure

The risk score included 36 pollutants persistently found in the environment

Author | Noah Fromson

graphic of a blood vial and petri dish
Jacob Dwyer, Justine Ross, Michigan Medicine


Over the last decade, research at Michigan Medicine has shown how exposure to toxins in the environment, such as pesticides and carcinogenic PCBs, affect the risk of developing and dying from amyotrophic lateral sclerosis. 

Now, investigators have developed an environmental risk score that assesses a person’s risk for developing ALS, as well as for survival after diagnosis, using a blood sample.

The results are published in the Journal of Neurology, Neurosurgery and Psychiatry.

SEE ALSO: Early Pesticide Exposure Contributes to Faster ALS Progression

“For the first time, we have a means collecting a tube of blood and looking at a person’s risk for ALS based on being exposed to scores of toxins in the environment,” said first author Stephen Goutman, M.D., M.S., director of the Pranger ALS Clinic and associate director of the ALS Center of Excellence at University of Michigan.

Researchers obtained over 250 blood samples from participants in Michigan both with and without ALS. They calculated individual risk and survival models using 36 persistent organic pollutants.

Several individual pollutants were significantly associated with ALS risk. However, the risk for developing the disease was most strongly represented by a mixture of pesticides in the blood.

SEE ALSO: ALS risk higher among production workers, those exposed to metals, volatile compounds on job

When considering the mixture of these pollutants, a person who was in the highest group of exposure had twice the risk of developing ALS compared to someone in the lowest group of exposure.

“Our results emphasize the importance of understanding the breadth of environmental pollution and its effects on ALS and other diseases,” said senior author Eva Feldman, M.D., Ph.D., James W. Albers Distinguished Professor at U-M, the Russell N. DeJong Professor of Neurology at U-M Medical School and director of the NeuroNetwork for Emerging Therapies at Michigan Medicine.

The research team’s first understanding of the environment’s impact on ALS came in 2016 when investigators found elevated levels of pesticides in the blood of patients with the disease.

They later uncovered that exposure to organic pollutants advances ALS progression and contributes to worse outcomes.

“When we can assess environmental pollutants using available blood samples, that moves us toward a future where we can assess disease risk and shape prevention strategies,” Feldman said.

“Environmental risk scores have been robustly associated with other diseases, including cancers, especially when coupled with genetic risk. This is a burgeoning application that should be further studied as we deal with the consequences of pollutants being detected throughout the globe.”

Additional authors include Jonathan Boss, Dae-Gyu Jang, Ph.D., Bhramar Mukherjee, Ph.D., Rudy J. Richardson, Ph.D., and Stuart Batterman, Ph.D., all of University of Michigan.

This research was supported by the National ALS Registry/Agency for Toxic Substances and Disease Registry at the CDC (grants 1R01TS000289, CDC/ATSDR 200-2013-56856).

This research was also supported by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Environmental Health Sciences and the National Center for Advancing Translational Sciences at the National Institutes (grants K23ES027221, R01ES030049, R01NS127188, UL1TR002240). Additional support from the NeuroNetwork for Emerging Therapies, the NeuroNetwork Therapeutic Discovery Fund, the Peter R. Clark Fund for ALS Research, the Sinai Medical Staff Foundation, and Scott L. Pranger, University of Michigan.

Paper cited: “Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort,”  Journal of Neurology, Neurosurgery and Psychiatry. DOI: 10.1136/jnnp-2023-332121


Stephen Goutman, MD, photo

Stephen Goutman, MD, MS

Director, Pranger ALS Clinic
Associate Director, ALS Center of Excellence
Associate Professor of Neurology
Department of Neurology
Ann Arbor MI 48109-2200
Pathogenesis and Clinical Care for ALS
photo of phd student jonathan boss

Jonathan Boss, BS, MS

Doctoral Candidate, Biostatistics
Bhramar Mukherjee, PhD

Bhramar Mukherjee, PhD

John D. Kalbfleisch Collegiate Professor of Biostatistics
Chair of Biostatistics
Professor, Epidemiology
Professor, Global Public Health, School of Public Health
Research Professor, Michigan Institute of Data Science
Associate Director for Quantitative Data Sciences, University of Michigan Rogel Cancer Center
School of Public Health
1415 Washington Heights
Ann Arbor, Michigan 48109-2029
Stuart Batterman

Stuart Batterman, PhD

Professor of Environmental Health Sciences, School of Public Health
Professor of Global Public Health, School of Public Health
Professor of Water Resources and Environmental Engineering, College of Engineering
School of Public Health
1415 Washington Heights
Ann Arbor, Michigan 48109-2029
Gene-Occupational Risk in ALS
portrait of Dr. Eva Feldman

Eva Feldman, MD, PhD

James W. Albers Distinguished University Professor of Neurology
Russell N. DeJong Professor of Neurology
Director, NeuroNetwork for Emerging Therapies
Director, ALS Center of Excellence