"We investigated how dysregulated Wnt signaling in patients with familial adenomatous polyposis (FAP) promotes polyp formation in the stomach. Analysis of human FAP organoids and genetic mouse models showed that heterozygous loss of APC optimally drives cellular proliferation in the corpus region of the stomach while homozygous APC loss is not tolerated. Our findings contextualize the abundant yet benign nature of gastric polyps in FAP patients."
