Jason Hearn

Jason Hearn, MD

Associate Professor

UH B2C490
1500 E Medical Center Dr
Ann Arbor, MI 48109

734-936-4300

Clinical Contacts

734-936-4300

Administrative Contact

Biography

Dr. Hearn is an Associate Professor in the Department of Radiation Oncology at the University of Michigan. He completed his medical training at Harvard Medical School and his residency in radiation oncology at Cleveland Clinic. Dr. Hearn investigates mechanisms by which prostate cancer may become resistant to current treatments.

Dr. Hearn also treats bladder cancer and has been impressed by the promising responses (sometimes dramatic and long-lasting) that some patients with bladder cancer have when treated with immunotherapy to harness the body’s immune system. He is interested in the intersection of immunotherapy and radiation therapy.

Additionally, Dr. Hearn is interested in novel techniques to improve the safety and efficacy of radiation therapy for lung cancer by modulating cytokines relevant to lung injury.

Areas of Interest

  • Prostate cancer
  • Bladder cancer
  • Lung cancer
  • Pediatric (childhood) malignancies

Clinical Interests

  • Genitourinary cancers (prostate, bladder, kidney/renal, urinary tract, testicular, and penile)
  • Bladder preservation therapy
  • Stereotactic body radiotherapy (SBRT; especially prostate SBRT and lung SBRT)
  • Thoracic tumors (lung, esophageal, thymic neoplasms, and mesothelioma)
  • Pediatric (childhood) malignancies
  • Conventional radiation therapy
  • Intensity modulated radiation therapy (IMRT)
  • Image-guided radiation therapy (IGRT)

Honors & Awards

2018    Association of Residents in Radiation Oncology (ARRO) Educator of the Year Award
2017    Top Ten Clinical Research Achievement Award (national competition)
2015    U.S. Department of Defense Award: Prostate Cancer Research Program
2015    Prostate Cancer Foundation Challenge Award
2015    Conquer Cancer Foundation of ASCO Merit Award
2015    RSNA Roentgen Research Award
2013    Jerrold P. Saxton Award for Clinical Excellence
2004    Beta Beta Beta National Biological Honor Society
2004    Blue Key National Honor Society
2004    Delta Epsilon Sigma National Honor Society
2003    Alpha Lambda Delta National Honor Society
2002-2006  Dr. & Mrs. Mario J. Campagna Scholarship
2002-2006  Hopkin Jenkins Scholarship
2002-2006  Robert C. Byrd Honors Scholarship
2002-2006  Siegert Scholarship
2002-2006  Simon Benson Foundation Scholarship
2002-2006  University of Portland President’s Scholarship

Credentials

  • MD, Harvard Medical School, 2010
  • Medical License: State of Michigan
  • Board Certification: Radiation Oncology

Grants

  • (PI: Hearn), 2016-2020, Bayer Corporation through a consortium with Hoosier Cancer Research Network: Androgen Deprivation Therapy with or without Radium-223 Dichloride in Patients with Newly Diagnosed Metastatic Prostate Cancer with Bone Metastases.
  • (PI: Hearn), 2015-2019, United States Department of Defense Physician Training Award: Germline variation in HSD3B1 as a novel biomarker in prostate cancer.

Published Articles or Reviews

  1. Tobalske BW, Hearn JWD, Warrick DR.: Aerodynamics of Intermittent Bounds in Flying Birds Experiments in Fluids 46(5): 963-973, 2009.
  2. Hearn JWD, Videtic GMM, Djemil T, Stephans KL.: Salvage Stereotactic Body Radiotherapy (SBRT) for Local Failure after Primary Lung SBRT International Journal of Radiation Oncology, Biology, Physics 90(2): 402-406, 2014. PM25017480
  3. Kotecha R, Marwaha G, Hearn JWD, Weller MA, Kupelian P, Reddy CA, Ciezki JP, Stephans K, Tendulkar RD: A Comparison of Long-Term Treatment-Related Toxicities between Moderately Hypofractionated and Conventionally Fractionated Dose-Escalated Radiation Therapy for Localized Prostate Cancer. International Journal of Radiation Oncology 90(1): 423-424, 2014. (In Press)
  4. Spratt D, Jackson W, Abugharib A, Tomlins S, Dess R, Soni P, Lee J, Zhao S, Cole A, Zumsteg Z, Sandler H, Hamstra D, Hearn JWD, Palapattu G, Mehra R, Morgan T, and Feng F: Independent Validation of the Prognostic Capacity of the ISUP Prostate Cancer Grade Grouping System for Radiation Treated Patients with Long-term Follow-up Prostate Cancer and Prostatic Diseases 19(3): 292-7, 2016. PMID 27215611
  5. Hearn JWD, AbuAli G, Reichard CA, Reddy CA, Magi-Galluzzi C, Chang K-H, Carlson R, Rangel L, Reagan R, Davis BJ, Karnes RJ, Kohli M, Tindall D, Klein EA, and Sharifi N: HSD3B1 and Resistance to Androgen-Deprivation Therapy in Prostate Cancer: A Retrospective, Multicohort Study Lancet Oncology 17(10): 1435-1444, 2016. PMC5135009
  6. Dess R, Sun Y, Matuszak M, Sun G, Soni P, Bazza L, Murthy V, Hearn JWD, Kong F, Kalemkerian G, Hayman J, Ten Haken R, Lawrence T, Schipper M, Jolly S.: Cardiac Events after Radiation Therapy: Combined Analysis of Prospective Multicenter Trials for Locally Advanced Non-Small Cell Lung Cancer Journal of Clinical Oncology 35(13): 1395-1402, 2017. PMC5455464
  7. Jackson WC, Desai N, Abugharib A,Tumati V, Dess R, Lee J, Zhao Z, Soliman M, Folkert, M, Laine A, Hannan R, Zumsteg Z, Sandler H, Hamstra D, Montgomery J, Miller D, Kozminski M, Hollenbeck B, Hearn JWD, Palapattu G, Tomlins S, Mehra R, Morgan T, Feng F, Spratt D.: Anatomic Patterns of Recurrence Following Biochemical Relapse after Post-Prostatectomy Salvage Radiation Therapy: A Multi- Institutional Study BJU International 120(3): 351-357, 2017. 28139024
  8. Hawkins PG, Boonstra PS, Hobson ST, Hearn JWD, Hayman JA, Ten Haken RK, Matuszak MM, Stanton P, Kalemkerian GP, Ramnath N, Lawrence TS, Schipper MJ, Kong (Spring) FM, Jolly S.: Radiation-induced lung toxicity in non-small-cell lung cancer: Understanding the interactions of clinical factors and cytokines with the dose-toxicity relationship Radiotherapy and Oncology 125 (2017): 66-72, 2017. PM28947099/PMCID: 5645039
  9. Sun Y, Hawkins PG, Bi N, Tewari M, Hearn JWD, Hayman JA, Kalemkerian GP, Lawrence TS, Ten-Haken RK, Matuszak MM, Kong FM, Jolly S, Schipper MJ: Serum microRNA Signature Predicts Response to High-dose Radiotherapy in Locally Advanced Non-Small-Cell Lung Cancer International Journal of Radiation Oncology, Biology, Physics 100(Number 1): 107-114, 2017. PM29051037 /PMC5736451
  10. Jackson WC, Suresh K, Tumati V, Dess RT, Soni PD, Zhao SG, Zumstmeg ZS, Hannan R, Hollenbeck BK, George A, Kaffenberger SD, Salami SS, Hearn JWD, Morgan TM, Mehra R, Schipper M, Feng FY, Desai NB, Spratt DE: Impact of Biochemical Failure After Salvage Radiation Therapy on Prostate Cancer– specific Mortality: Competition Between Age and Time to Biochemical Failure European Urology. 1(4): 276-282, 2018. PM31100248
  11. Hearn JWD, Xie W, Nakabayashi M, Almassi N, Reichard CA, Pomerantz M, Kantoff PW, Sharifi N: Association of HSD3B1 Genotype with Response to Androgen-Deprivation Therapy for Biochemical Recurrence after Radiotherapy for Localized Prostate Cancer JAMA Oncol 4(4): 558-562, 2018. PMC5933377
  12. Ramey SJ, Agrawal S, Abramowitz MC, Moghanaki D, Pisansky TM, Efstathiou JA, Michalski JM, Spratt DE, Hearn JWD, Koontz BF, Liauw S, Pollack A, Anscher MS, Den RB, Stephans KL, Zietman AL, Lee WR, Stephenson AJ, Tendulkar RD.: Multi-Institutional Evaluation of Elective Nodal Irradiation and/or Androgen Deprivation Therapy with Post-Prostatectomy Salvage Radiotherapy for Prostate Cancer European Urology. 2018 Jul; 74(1):99-106. doi: 10.1016/j.eururo.2017.10.009. Epub 2017 Nov 9.. (In Press) PMID: 29128208
  13. Jackson WC, Suresh K, Tumati V, Allen SG, Dess RT, Salami SS, George A, Kaffenberger SD, Miller DC, Hearn JWD, Jolly S, Mehra R, Hollenbeck BK, Palapattu GS, Schipper M, Feng FY, Morgan TM, Desai NB, Spratt DE.: Intermediate Endpoints After Postprostatectomy Radiotherapy: 5-Year Distant Metastasis to Predict Overall Survival European Urology [Epub ahead of print]: pii: S0302-2838(17)31070-9. doi:10.1016/j.eururo.2017.12.023, 2018. PMID: 2930651
  14. Litzenberg DW, Muenz DG, Archer PG, Jackson WC, Hamstra DA, Hearn JWD, Schipper MJ, Spratt DE: Changes in Prostate Orientation Due to Removal of a Foley Catheter Medical Physics. 45(4): 1369-1378, 2018. PMID 29474748
  15. Hwang WL, Tendulkar RD, Niemierko A, Agrawal S, Stephans KL, Spratt DE, Hearn JWD, Koontz BF, Lee WR, Michalski JM, Pisansky TM, Liauw SL, Abramowitz MC, Pollack A, Moghanaki D, Anscher MS, Den RB, Zietman AL, Stephenson AJ, Efstathiou JA.: Comparison Between Adjuvant and Early-Salvage Postprostatectomy Radiotherapy for Prostate Cancer With Adverse Pathological Features JAMA Oncology [Epub ahead of print]: e175230. doi: 10.1001/jamaoncol.2017.5230, 2018. PMID: 29372236
  16. Piert M, Shankar PR, Montgomery J, Kunju LP, Rogers V, Siddiqui J, Rajendiran T, Hearn JWD, George A, Shao X, Davenport MS.: Accuracy of tumor segmentation from multi-parametric prostate MRI and 18Fcholine PET/CT for focal prostate cancer therapy applications EJNMMI Res 8(1): 23, 2018. PMC5869349
  17. Berlin A, Moraes FY, Sanmamed N, Glicksman R, Koven A, Espin-Garcia O, Leite ETT, Silva JLF, Gadia R, Nesbitt M, Catton CN, Kaffenberger S, Salami SS, Morgan TM, Hearn JWD, Jackson WC, Mehra R, Chung P, Fleshner NE, Zumsteg ZS, Dess RT, Feng FY, Finelli A, Spratt DE: International Multicenter
    Validation of an Intermediate Risk Subclassification of Prostate Cancer Managed with Radical Treatment without Hormone Therapy. J Urol 201(2): 284-291, 2019. PM30153435
  18. Christensen RE, Nause-Osthoff RC, Waldman JC, Spratt DE, Hearn, JWD: Adverse Events in Radiation Oncology: A Case Series from Wake Up Safe, the Pediatric Anesthesia Quality Improvement Initiative. Paediatr Anaesth 29(3): 265-270, 2019. PM30580487
  19. Foster B, Jackson W, Foster C, Dess R, Abu-Isa E, McLaughlin PW, Merrick G, Hearn J, Spratt D, Liauw S, Hamstra D: Application of a Prognostic Stratification System for High-risk Prostate Cancer to Patients Treated With Radiotherapy: Implications for Treatment Optimization. Am J Clin Oncol 42(4): 382-390, 2019. PM30724780
  20. Paradis KC, Mayo C, Owen D, Spratt DE, Hearn J, Rosen B, Kashani R, Moran J, Tatro DS, Beeler W, Vineberg K, Smith DC, Matuszak MM: The Special Medical Physics Consult Process for Reirradiation Patients. Adv Radiat Oncol 4(4): 559-565, 2019. PM31681862/PMC6817723
  21. Schneider BJ, Ismaila N, Aerts J, Chiles C, Daly ME, Detterbeck FC, Hearn JWD, Katz SI, Leighl NB, Levy B, Meyers B, Murgu S, Nekhlyudov L, Santos ES, Singh N, Tashbar J, Yankelevitz D, Altorki N: Lung Cancer Surveillance After Definitive Curative-Intent Therapy: ASCO Guideline. J Clin Oncol:
    JCO1902748, 2019. (In Press) PM31829901
  22. Kapoor R, Deek MP, McIntyre R, Raman N, Kummerlowe M, Chen I, Gaver M, Wang H, Denmeade S, Lotan T, Paller C, Markowski M, Carducci M, Eisenberger M, Beer TM, Song DY, DeWeese TL, Hearn JW , Greco S, DeVille C, Desai NB, Heath EI, Liauw S, Spratt DE, Hung AY, Antonarakis ES, Tran PT: A
    phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA). BMC Cancer 19(1): 572, 2019. PM31196032/PMC6567492
  23. Jackson WC, Silva J, Hartman HE, Dess RT, Kishan AU, Hearn JWD, Mehra R, Morgan TM, Kaffenberger S, Nguyen PL, Desai N, Feng FY, Zumsteg ZS, Spratt DE.: Stereotactic Body Radiotherapy for Localized Prostate Cancer: A Systematic Review and Meta-Analysis of Over 6,000 Patients Treated On Prospective Studies. Int J Radiat Oncol Biol Phys 104(4): 778-789, 2019. PM30959121/PMC6770993
  24. Qin A, Rengan R, Lee S, Santana-Davila R, Goulart BHL, Martins R, Baik C, Kalemkerian GP, Hassan KA, Schneider BJ, Hayman JA, Jolly S, Hearn J, Lawrence TS, Towlerton AMH, Tewari M, Thomas D, Zhao L, Brown N, Frankel TL, Warren EH, Ramnath N: A Pilot Study of Atezolizumab plus
    Hypofractionated Image-guided Radiotherapy for the Treatment of Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys: 2019. (In Press) PM31756415
  25. Hearn JWD, Sweeney CJ, Almassi N, Reichard CA, Reddy CA, Li H, Hobbs B, Jarrard DF, Chen YH, Dreicer R, Garcia JA, Carducci MA, DiPaola RS, Sharifi N: HSD3B1 Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer. JAMA Oncol e-published ahead of print: Online, 2020.
    PM32053149
  26. Jackson WC, Hartman H, Dess R, Bierer S,Payal S, Hearn JWD, Reichert A, Kishan A, Mahal BA, Zumsteg Z, Efstathiou, Kaffenberger S, Morgan T, Mehar R, Showalter T, Krauss D, Nguyen P, Schipper M, Feng F, Sandler H, Hoskin P, Roach M, Spratt DE: Addition of androgen-deprivation therapy or
    brachytherapy boost to external beam radiotherapy for men with localized prostate cancer: A network meta-analysis of randomized trials Journal Of Clinical Oncology. (In Press)

Book Chapters

  1. Qin A, Rengan R, Lee S, Santana-Davila R, Goulart BHL, Martins R, Baik C, Kalemkerian GP, Hassan KA, Schneider BJ, Hayman JA, Jolly S, Hearn J, Lawrence TS, Towlerton AMH, Tewari M, Thomas D, Zhao L, Brown N, Frankel TL, Warren EH, Ramnath N: A Pilot Study of Atezolizumab plus Hypofractionated Image-guided Radiotherapy for the Treatment of Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys: 2019. (In Press) PM31756415
  2. Hearn JWD, Sweeney CJ, Almassi N, Reichard CA, Reddy CA, Li H, Hobbs B, Jarrard DF, Chen YH, Dreicer R, Garcia JA, Carducci MA, DiPaola RS, Sharifi N: HSD3B1 Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer. JAMA Oncol e-published ahead of print: Online, 2020. PM32053149
  3. Jackson WC, Hartman H, Dess R, Bierer S,Payal S, Hearn JWD, Reichert A, Kishan A, Mahal BA, Zumsteg Z, Efstathiou, Kaffenberger S, Morgan T, Mehar R, Showalter T, Krauss D, Nguyen P, Schipper M, Feng F, Sandler H, Hoskin P, Roach M, Spratt DE: Addition of androgen-deprivation therapy or brachytherapy boost to external beam radiotherapy for men with localized prostate cancer: A network meta-analysis of randomized trials Journal Of Clinical Oncology. (In Press)
Locations

1500 E Medical Center Dr
Ann Arbor, MI 48109-5010

734-936-4320