Biography
Srijan Sen is the Director of the Frances and Kenneth Eisenberg and Family Depression Center and the Frances and Kenneth Eisenberg Professor of Depression and Neurosciences.
Dr. Sen’s research focuses on the interactions between genes and the environment and their effect on stress, anxiety, and depression. His research includes leadership of the large Intern Health Study, which focuses on studying physicians in their first year of post-medical school training using genomics, mobile technology and other tools to understand how stress leads to depression. As of February 2021, the study includes data from more than 25,000 interns at over 100 U.S. and Chinese teaching hospitals
Areas of Interest
- Depression
- Genes
- Gene x Environment Interactions
- Medical Education
- Digital Psychiatry
Featured News
Critical steps and more research needed to support physicians’ mental health, experts say
Researchers who have led work on stress, depression and well-being in physicians say progress is being made but more can be done, including addressing key research questions

From ‘trial and error’ to targeted precision: $17.9M grant accelerates U-M mental health research
Study will combine patients’ self-reports with data from mobile apps, wearable devices, genetic samples and clinical records to improve the success of first-time mental health treatment

Support from others in stressful times can ease impact of genetic depression risk
Study in first-year doctors and recently widowed older adults shows greatest impact of social support in those with highest polygenic risk scores for depression

In stressful jobs, depression risk rises with hours worked, study in new doctors finds
In “emulated” clinical trial, longer work weeks were strongly linked to larger rise in depression symptoms, pushing some first-year resident physicians into moderate or severe depression range.

U-M study: Depression incidence and factors among residents are similar in China and US
Though a world apart, first-year residents in the United States and China have more in common than they might imagine, including bouts of depression, a new study suggests.
Credentials
- Yale (residency)
- University of Michigan (MD and PhD)
- Oxford University (undergrad)
- Cornell University (undergrad)