PRIORI - Longitudinal Voice Patterns in Bipolar Disorder

"Predicting Individual Outcomes for Rapid Intervention"
Longitudinal Voice Patterns in Bipolar Disorder

One of the main symptoms of bipolar disorder is changes in speech. During mania, speech increases in rate, rhythm, and volume. During depression, the opposite occurs. The purpose of this study is to use special computer software to analyze the sound waves of speech and identify changes that may happen before a mood episode.

Participants in this study are given a smart phone that is slightly modified to include an application that records outgoing speech. Voice patterns will be analyzed by computer software that is programmed to detect changes in the physical elements of speech such as amount of speech, pitch, rate, rhythm, and volume.

All analyses will be computer based, speech is encrypted, and the research team will not listen to the actual contents of speech. In addition, weekly recorded clinical assessments will be conducted for the duration of the study. Participants for this study will be recruited from the Prechter flagship Longitudinal Study of Bipolar Disorder. Both participants with bipolar disorder and unaffected controls will be examined for comparison.

This study has received approval from IRBMED: HUM00052163

The PRIORI app and mood prediction pipeline