Bipolar spectrum disorders (BSDs) are often accompanied by anxiety and depression, with each being a risk factor for the other. While the negative impact of these symptoms on BSDs is well-documented, little is known about the temporal dynamics between anxiety and depression. Understanding this bidirectional relationship can inform more effective treatment strategies for BSD patients. To this end, the present study, led by Hanjoo Kim, Ph.D. and mentored by Sarah Sperry, Ph.D., will examine the dynamic relationship between anxiety and depression over an average of 11 years in individuals with BSDs. The present study will analyze data from participants with BSDs (i.e., BD I, BD II, BD not otherwise specified, schizoaffective bipolar type) in the Prechter Longitudinal Study of Bipolar Disorder who had been assessed for at least five years. Bimonthly measurements of anxiety and depression will be analyzed using Dynamic Structural Equation Modeling (DSEM). In addition to testing cross-lagged effects, this study will also explore whether temporal dynamics differ based on demographic characteristics.
To learn more about participating in the Prechter Longitudinal Study of Bipolar Disorder, please contact a research associate at 1-877-UM GENES (1-877-864-3637) or [email protected]. The Prechter Longitudinal Study of Bipolar Disorder is approved by IRBMED HUM00000606.