Frank Kwarcinski
Research Investigator
Pharmacology
Pharmacology
1150 W. Medical Center Dr, MSRBIII, Rm 1240
Ann Arbor, MI 48109
[email protected]

Available to mentor
Frank Kwarcinski
Research Investigator
  • Research Overview
  • Recent Publications
    • Research Overview

    1. Examining G protein-coupled signaling pathways by determining the factors that regulate G protein folding and cellular abundance.

    2. Structural and biochemical characterization of adhesion GPCRs for mechanism of action and pathogenesis studies.

    3. Assay development and identification of novel chemical inhibitors for both adhesion GPCRs and soluble protein targets involved in G protein signaling dysregulation.

    Recent Publications See All Publications
    • Journal Article
      Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB.
      Ong HW, de Silva C, Avalani K, Kwarcinski F, Mansfield CR, Chirgwin M, Truong A, Derbyshire ER, Zutshi R, Drewry DH. ACS Med Chem Lett, 2023 Dec 14; 14 (12): 1774 - 1784. DOI:10.1021/acsmedchemlett.3c00354
      PMID: 38116430
    • Journal Article
      GPR114/ADGRG5 is activated by its tethered peptide agonist because it is a cleaved adhesion GPCR.
      Bernadyn TF, Vizurraga A, Adhikari R, Kwarcinski F, Tall GG. J Biol Chem, 2023 Oct; 299 (10): 105223 DOI:10.1016/j.jbc.2023.105223
      PMID: 37673336
    • Preprint
      Characterization of 2,4-dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9 and PfPKB
      Ong HW, de Silva C, Avalani K, Kwarcinski F, Mansfield C, Chirgwin M, Truong A, Derbyshire E, Zutshi R, Drewry D. ChemRxiv, DOI:10.26434/chemrxiv-2023-1fg86
    • Proceeding / Abstract / Poster
      The Adhesion GPCR GPR114/ADGRG5 is Activated by its Tethered-Peptide-Agonist Following Receptor Fragment Dissociation
      Bernadyn T, Adhikari R, Vizurraga A, Kwarcinski F, Tall G. Journal of Pharmacology and Experimental Therapeutics, 2023 Jun; 385 (S3): 478 DOI:10.1124/jpet.122.173960
    • Journal Article
      Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms.
      Papasergi-Scott MM, Kwarcinski FE, Yu M, Panova O, Ovrutsky AM, Skiniotis G, Tall GG. Structure, 2023 May 4; 31 (5): 553 - 564.e7. DOI:10.1016/j.str.2023.02.011
      PMID: 36931277
    • Journal Article
      Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore.
      Ong HW, Truong A, Kwarcinski F, de Silva C, Avalani K, Havener TM, Chirgwin M, Galal KA, Willis C, Krämer A, Liu S, Knapp S, Derbyshire ER, Zutshi R, Drewry DH. Eur J Med Chem, 2023 Mar 5; 249: 115043 DOI:10.1016/j.ejmech.2022.115043
      PMID: 36736152
    • Journal Article
      SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4.
      Tiek D, Wells CI, Schröder M, Song X, Alamillo-Ferrer C, Goenka A, Iglesia R, Lu M, Hu B, Kwarcinski F, Sintha P, de Silva C, Hossain MA, Picado A, Zuercher W, Zutshi R, Knapp S, Riggins RB, Cheng S-Y, Drewry DH. Curr Res Chem Biol, 2023 3: DOI:10.1016/j.crchbi.2023.100045
      PMID: 38009092
    • Preprint
      SGC-CLK-1 (CAF-170) a chemical probe for the Cdc2-Like kinases CLK1, CLK2, and CLK4
      Tiek D, Wells CI, Schröder M, Song X, Alamillo-Ferrer C, Goenka A, Iglesia R, Lu M, Hu B, Kwarcinski F, Sintha P, de Silva C, Hossain MA, Picado A, Zuercher W, Zutshi R, Knapp S, Riggins RB, Cheng S-Y, Drewry DH. bioRxiv, DOI:10.1101/2022.12.15.520623