Technology Innovation

Research Projects

Cagri G. Besirli, MD, PhD

Ophthalmic device and drug development

Our group is also interested in improving delivery of care for patients with ophthalmic diseases using novel biomedical tools.  Our current research collaborations include developing a medical device to deliver rapid, non-pharmacologic anesthesia for in-office ophthalmic procedures, a hydrogel-based drug delivery platform for intravitreal injection of multiple therapeutic agents, and the development of nanoparticles and novel kinase inhibitors for the treatment of ocular cancer.

Grant Support
  • Paul R. Lichter, MD Discovery Discovery Fund
    Besirli (PI)
    University of Michigan
    Enhanced control over the release of multiple drugs for ocular diseases: Layer-by-layer assembly of drug-encapsulated particles and polyelectrolyte solutions

Joshua R. Ehrlich, MD, MPH

Head-Mounted Display Technology in Low Vision 

Few interventions exist to improve the vision-dependent functioning of patients with severe peripheral vision loss. For this reason, our team is exploring the potential benefits of head-mounted display technology for this low vision population. We are examining the effect of this technology on a host of clinical, gait, mobility and quality-of-life outcomes. We are also working to optimize this technology so that it will best meet the needs of our patients. 

Grant Support

Michigan Institute for Clinical and health Research
Role: PI
Optical Head-Mounted Display Technology for Low Vision Rehabilitation

Yannis M. Paulus, MD, FACS

Ophthalmology is one of the most technology-driven medical specialties with numerous recent advances due to improvements in technology. The Paulus Advanced Eye Imaging and Laser Laboratory focuses on applying physics, bioengineering, optics, nanotechnology, and mathematical modeling to develop novel retinal imaging systems and laser therapies.  Our group has co-developed a novel, inexpensive system for providing tele-ultrasound, co-founded a retinal imaging company, and investigate pattern scanning laser photocoagulation (PASCAL), laser-tissue interactions, and restorative retinal laser therapy to create minimally traumatic retinal laser therapy. They have developed more targeted laser therapy through modulation of pulse duration (from millisecond to nanosecond pulse durations), wavelength, beam characteristics, and physical modulators. In addition, our group seeks to use the synergistic effect of combination therapies, for example with our newly developed and patented Photo-mediated Ultrasound Therapy (PUT), which uses a combination of ultra-short nanosecond laser combined with ultrasound to selectively cause microcavitation bubbles and treatment of pathologic microvasculature. In addition, our group works to develop new imaging platforms, such as photoacoustic microscopy, and multimodal molecular imaging of the retina and choroid for retinal ischemic diseases, including macular degeneration, diabetic retinopathy, vein occlusions, and sickle cell retinopathy.

Grant Support

  • 4K12EY022299, National Institutes of Health, National Eye Institute
    PI: Thomas Gardner
    05/01/2016 – 04/30/2018
    Real-time In Vivo Visualization of the Molecular Processes in Choroidal Neovascularization
    Role: Scholar
  • Fight for Sight – International Retinal Research Foundation FFSGIA16002
    PI: Yannis M. Paulus
    07/01/2016 – 12/31/2017
    Realtime In Vivo Visualization of the Molecular Processes in Retinal and Choroidal Neovascularization
    Role: PI
  • Alliance for Vision Research
    PI: Yannis M. Paulus
    03/01/2017 – 02/28/2018
    Photo-mediated Ultrasound Therapy as a Novel Adjunct Therapy for Macular Degeneration
    Role: PI
  • Knights Templar Eye Foundation
    PI: Tapan Patel
    07/01/2017 – 06/30/2018
    Smartphone-based Wide-Field Fundus Photography for Diagnosis and Telemedicine in Pediatric Retinal Diseases
    Role: Preceptor

Kwoon Y. Wong, PhD

The Wong lab is developing novel lighting technologies that enhance alertness and productivity during the daytime, and an inexpensive smartphone-based eyewear for persons with low vision.

Grant Support

  • National Eye Institute
  • Promobilia Foundation (Sweden)
  • MCubed (University of Michigan)


Related Faculty Bios

Dr. Cagri Besirli

Cagri G. Besirli, MD, PhD

Skillman Career Development Professor of Pediatric Ophthalmology
Associate Professor, Ophthalmology and Visual Sciences
Dr. Kwoon Wong

Kwoon Y. Wong, PhD

Associate Professor, Ophthalmology and Visual Sciences
Associate Professor, Molecular, Cellular & Developmental Biology
Office: 734-936-5068; Lab: 734-936-8548