Guohua Xi, M.D.

Associate Director, Crosby Neurosurgical Laboratories
Richard C. Schneider Research Professor, Neurosurgery
Professor, Neurosurgery

Areas of Interest

Dr. Xi's research interests are mechanisms of brain injury after hemorrhagic stroke and preconditioning-induced neuroprotection.  His work has demonstrated that iron contributes to brain edema formation and neurodegeneration following intracerebral hemorrhage and has resulted in a deferoxamine clinical trial for intracerebral hemorrhage.


  • 2012-2019  Mechanisms of brain injury after intraventricular hemorrhage; Sponsor: NIH
  • 2012-2018  Mechanisms of early brain injury after subarachnoid hemorrhage; Sponsor: NIH
  • 2012-2018  Futility study of deferoxamine mesylate in intracerebral hemorrhage (iDEF); Sponsor: NIH
  • 2015-2019  Lipocalin-2 and intracerebral hemorrhage-induced brain injury; Sponsor: NIH
  • 2015-2020  Iron, minocycline, and brain injury after intracerebral hemorrhage; Sponsor: NIH
  • 2016-2021  Targeting CD47 to aid in clearing intracerebral hemorrhage; Sponsor: NIH
  • 2017-2019  Brain iron quantification based on MRI in intracerebral hemorrhage; Sponsor: NIH
  • 2018-2023  Early hemolysis and hemoglobin toxicity in intracerebral hemorrhage; Sponsor: NIH

Published Articles or Reviews

Spontaneous intracerebral hemorrhage (ICH)

  • Xi G, Wagner KR, Keep RF, Hua Y, de-Courten Myers GM, Broderick JP, Brott TG, and Hoff JT. The role of blood clot formation on early edema development following experimental intracerebral hemorrhage. Stroke 1998; 29:2580-2586.
  • Xi G, Hua Y, Keep RF, Younger JG, Hoff JT. Systemic complement depletion diminishes perihematomal brain edema. Stroke 2001; 32:162-167.
  • Cao S, Zheng M, Hua Y, Chen G, Keep RF, Xi G. Hematoma changes during clot resolution after experimental intracerebral hemorrhage. Stroke 2016;47:1626-31. PMCID: PMC5237112
  • Wilkinson DA, Keep RF, Hua Y, Xi G. Hematoma clearance as a therapeutic target in intracerebral hemorrhage: from macro to micro. J Cereb Blood Flow Metab 2018; 38:741-745. PMCID: PMC5888862

Translational stroke research

  • Okauchi M, Hua Y, Keep RF, Morgenstern LB, Xi G. Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats. Stroke 2009; 40:1858-1863. PMCID: PMC2674519
  • Okauchi M, Hua Y, Keep RF, Morgenstern LB, Schallert T, Xi G. Deferoxamine treatment for intracerebral hemorrhage in aged rats: therapeutic time window and optimal duration. Stroke 2010; 41:375-382. PMCID: PMC2896218
  • Xie Q, Gu Y, Hua Y, Liu W, Keep RF, Xi G. Deferoxamine attenuates white matter injury in a piglet intracerebral hemorrhage model. Stroke 2014; 45:290-292. PMCID: PMC3886635

The role of thrombin

  • Xi G, Reiser G, Keep RF. The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective? J Neurochem 2003; 84:3-9.
  • Wang J, Hang J, Hua Y, Keep RF, Xi G. Role of protease-activated receptor-1 in brain injury after experimental global cerebral ischemia. Stroke 2012; 43:2476-2482. PMCID: PMC3429659

Intraventricular hemorrhage (IVH)

  • Chen Z, Gao C, Hua Y, Keep RF, Muraszko KM, Xi G. The role of iron in brain injury after intraventricular hemorrhage. Stroke 2011; 42:465-470. PMCID: PMC3078056
  • Gao F, Liu F, Chen Z, Hua Y, Keep RF, Xi G. Hydrocephalus after intraventricular hemorrhage: the role of thrombin. J Cereb Blood Flow Metab 2014; 34:489-494. PMCID: PMC3948129