Tiffany Braley, M.D., M.S.

Dr. Braley is an Associate Professor of Neurology and clinical neuroimmunologist who specializes in the treatment of multiple sclerosis and related disorders. She received her M.D. from Wayne State University in 2004 and Master’s degree in Clinical Research Design and Statistical Analysis from the University of Michigan School of Public Health in 2011. Dr. Braley’s research focuses on crucial connections between sleep disorders, the immune system, and neurological disorders (especially as they relate to patients with MS), and the treatment of chronic MS symptoms including fatigue. She also conducts clinical trials of MS therapeutics.

Dr. Braley prioritizes interdisciplinary patient-centered care, integrating this approach into the clinical, scholarly, and training missions of the U-M MS Center. Since joining the U-M Neurology faculty in 2011, Dr. Braley has worked to develop a productive, multidisciplinary clinical research program between the University of Michigan Neurology Neuroimmunology (MS) and Sleep Divisions, and Physical Medicine and Rehabilitation Department. To date, these partnerships have led to several important findings that have increased our understanding of sleep disorders, including their effects on persons with MS, and predictors of MS-related fatigue. Dr. Braley has also established a new first of its kind Multidisciplinary MS Fatigue and Sleep Clinic.  This clinic offers a unique service to patients with multiple sclerosis and related inflammatory disorders of the central nervous system. Dr. Braley also directs the MS and Clinical Neuroimmunology Fellowship program. 

Dr. Braley's Active and Recent Studies:

Comparing Treatments for Fatigue in Patients with Multiple Sclerosis (COMBO-MS) 

The purpose of this multicenter trial is to compare the effectiveness of telephone-based cognitive behavioral therapy, modafinil, or both for multiple sclerosis fatigue. Read more here. 

Mechanisms of cannabidiol in persons with MS: the role of sleep and pain phenotype

The purpose of this mechanistic clinical trial is to evaluate the effects of CBD on sleep in persons with MS and chronic pain, and explore changes in sleep as a mediator of the analgesic effects of CBD. Read more here. 

Pathways between OSA and cognitive decline in older women and men: a longitudinal population-based study

This study will use data from a nationally representative, multi-ethnic longitudinal cohort study of older adults, linked with Medicare claims datasets, to examine pathways between obstructive sleep apnea (OSA), OSA treatment, and cognitive decline among women and men. Read more here. 

A randomized trial of positive airway pressure therapy to treat cognitive dysfunction in MS patients with obstructive sleep apnea 

The purpose of this clinical trial is to evaluate the effects of continuous positive airway pressure therapy on cognitive function in people with MS who have obstructive sleep apnea. Read more here. 

Collaborations and Affiliations

• Sleep Disorders Centers 
• MS Fatigue and Sleep Clinic 
• Kratz Lab 
• Physical Medicine and Rehabilitation 
• The Chronic Pain and Fatigue Research Center 
• U-M Institute for Healthcare Policy & Innovation  
• Michigan Humane 
• Humane Society of Huron Valley
• Americas Committee for Treatment and Research in MS
• National MS Society
• American Academy of Sleep Medicine Foundation
• Sleep Research Society