BASIC Sleep Apnea Projects

Project Titles 

  • The epidemiology of sleep apnea in a bi-ethnic stroke population. (R01 HL098065)
  • Sleep Apnea Health Disparities in Mexican American Stroke Patients. (R01 NS070941)
  • Nocturnal rostral fluid shifts in stroke patients with sleep apnea. (R01HL123379)
  • Sleep apnea after stroke:  Implications for screening and treatment. (R01HL126700)


The University of Michigan Stroke Program investigates multiple aspects of post-stroke sleep apnea in patients in Corpus Christi, Texas.  (1) An NHLBI-funded ancillary study assessed the frequency of sleep-disordered breathing after stroke, and the relationship of this sleep disorder to stroke outcomes. (2) The NINDS-funded sleep apnea study is designed to investigate health disparities related to sleep apnea in stroke patients. (3) An NHLBI-funded ancillary study investigates the association between nocturnal rostral fluid shifts and sleep apnea severity. (4) Finally, an NINDS-funded longitudinal, population-based study of sleep apnea and stroke outcomes is performed to improve the identification and management of important sleep apnea after stroke, provide critical data to plan future clinical trials, and explore a potential target to reduce an important ethnic health disparity.

Sleep Study Staff

Principal Investigators:
  • Morgan Campbell, MD
Project Manager:
  • Erin Case, BA
  • Melinda Cox, Dr PH
Sleep Technologist:
  • Garnett L. Hegeman, III, RPSGT


Brown DL, Shafie-Khorassani F, Kim S, Chervin RD, Case E, Morgenstern LB, Yadollahi A, Tower S, Lisabeth LD. Sleep-disordered breathing is associated with recurrent ischemic stroke. Stroke. 2019 Mar;50(3):571-576. PMID: 30744545

Brown DL, Jiang X, Li C, Case E, Sozener CB, Chervin RD, Lisabeth LD. Sleep apnea screening is uncommon after stroke. Sleep Med. 2018 Sep 27. PMID: 30482619

Lisabeth LD, Scheer RV, Li C, Case E, Chervin RD, Zahuranec DB, Morgenstern LB, Garcia NM, Tower S, Brown DL. Intracerebral hemorrhage and sleep-disordered breathing. Sleep Med 2018;46:114-116.

Brown DL, Li C, Sánchez BN, Dunietz GL, Chervin RD, Case E, Garcia NM, Lisabeth LD. Lack of worsening of sleep-disordered breathing after recurrent stroke. J Clin Sleep Med 2018, 2018 May 15;14(5):835-839. PMID: 29734992

Brown DL, Li C, Chervin RD, Case E, Garcia NM, Tower SD, Lisabeth, LD. Wake-up stroke is not associated with sleep-disordered breathing in women. Neurology Clinical Practice 2018;8(1):8-14. PMID:29517077

McDermott M, Brown DL, Li C, Garcia NM, Case E, Chervin RD, Morgenstern LB, Lisabeth LD. Sex differences in sleep-disordered breathing after stroke: results from the BASIC project. Sleep Med 2018;43:54-59. PMID:29482813

Lisabeth LD, Sánchez BN, Chervin RD, Morgenstern LB, Zahuranec DB, Tower SD, Brown DL. High Prevalence of Post-Stroke Sleep Disordered Breathing in Mexican Americans. Sleep Med, in press.

Brown DL, Mowla A, McDermott M, Morgenstern LB, Hegeman G 3rd, Smith MA, Garcia NM, Chervin RD, Lisabeth LD. Ischemic Stroke Subtype and Presence of Sleep-Disordered Breathing: The BASIC Sleep Apnea Study. J Stroke Cerebrovasc Dis 2015; 24: 388-393.

De Lott LB, Lisabeth LD, Sánchez BN, Morgenstern LB, Smith MA, Garcia NM, Chervin RD, Brown DL. Prevalence of pre-stroke sleep apnea risk and short or long sleep duration in a bi-ethnic stroke population.Sleep Med 2014; 15: 1582-1585.

Brown DL, McDermott M, Mowla A, De Lott L, Morgenstern LB, Kerber KA, Hegeman G 3rd, Smith MA, Garcia NM, Chervin RD, Lisabeth LD. Brainstem infarction and sleep-disordered breathing in the BASIC sleep apnea study. Sleep Med 2014; 15: 887-91.

Brown DL, Chervin RD, Hegeman G 3rd, Smith MA, Garcia NM, Morgenstern LB, Lisabeth LD. Is technologist review of raw data necessary after home studies for sleep apnea? J Clin Sleep Med2014;10:371-375.

Reeves SL, Brown DL, Chervin RD, Morgenstern LB, Smith MA, Lisabeth LD. Agreement between stroke patients and family members for ascertaining pre-stroke risk for sleep apnea. Sleep Med 2014;15:121-124.

Kerber KA, Brown DL, Skolarus LE, Morgenstern LB, Smith MA, Garcia NM,  Lisabeth LD. Validation of the 12-Item Stroke-Specific Quality of Life Scale in a Bi-ethnic Stroke Population.  J Stroke Cerebrovasc Dis2013; 22: 1270-1272.

Schütz SG, Lisabeth LD, Shafie-Khorassani F, Case E, Sanchez BN, Chervin RD, Brown DL. Clinical phenotypes of obstructive sleep apnea after ischemic stroke: a cluster analysis. Sleep Med 2019; 60: 178-181.

Lisabeth LD, Sánchez BN, Lim D, Chervin RD, Case E, Morgenstern LB, Tower S, Brown DL. Sleep-disordered breathing and poststroke outcomes. Ann Neurol 2019; 86: 241-250.

Brown DL, Shafie-Khorassani F, Kim S, Chervin RD, Case E, Yadollahi A, Lisabeth LD. Do apneas and hypopneas best reflect risk for poor outcomes after stroke? Sleep Med 2019; 63: 14-17.

Brown DL, He K, Kim S, Hsu C-W, Case E, Chervin RD, Lisabeth LD. Prediction of sleep-disordered breathing after stroke. Sleep Med. 2020; 75: 1-6.

Schütz SG, Lisabeth LD, Hsu C-W, Kim S, Chervin RD, Brown DL. Central Sleep Apnea is Uncommon after Stroke. Sleep Med. in press.