Henry Paulson

Henry Paulson, MD, PhD

Lucile Groff Professor of Neurology
Professor, Neurology
Director, Alzheimer’s and Related Dementias


Henry L. Paulson, M.D., Ph.D., is the Lucile Groff Professor of Neurology for Alzheimer's Disease and Related Disorders in the Department of Neurology at the University of Michigan. Dr. Paulson joined the U-M faculty in 2007, and he currently directs the Michigan Institute for Neurodegenerative Diseases (MiND).

Dr. Paulson received his medical degree and doctorate from Yale University in 1990. He then completed a neurology residency and neurogenetics/movement disorders fellowships at the University of Pennsylvania. In 1997, he joined the Neurology faculty at the University of Iowa, where he remained until 2007.

Dr. Paulson's research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with a focus on hereditary ataxias and Alzheimer's disease. In 1997, his lab described abnormal protein aggregates in the so-called polyglutamine diseases, which now are recognized as a pathological hallmark in this important class of inherited diseases. Using test tube, cell-based and animal models, he has contributed to advances in the understanding of various neurodegenerative diseases. His lab also has helped pioneer the use of RNA interference as potential therapy for the many hereditary neurological disorders caused by "toxic" mutant genes.

Nationally, Dr. Paulson has directed popular courses at the American Academy of Neurology meetings, serves on the scientific advisory boards of numerous disease-related national organizations, and belongs to the Board of Scientific Counselors at the National Institute for Neurological Disorders and Stroke at the National Institutes of Health.

Among his awards, Dr. Paulson is an Ellison Medical Foundation New Scholar in Aging, a semifinalist for the W.M. Keck Foundation Young Scholars in Medical Research, and a recipient of the Paul Beeson Physician Faculty Scholar in Aging Award from the American Federation for Aging Research.

Areas of Interest

Neurodegenerative diseases caused by abnormal proteins; Spinocerebellar Ataxia type 3; RNA interference as potential therapy including studies of polyglutamine diseases and Alzheimer's disease; Protein quality control in normal brain function and in neurodegenerative diseases.

Clinical Interests

Neurology, Neurodegenerative diseases including movement disorders, ataxias and dementias.


Medical School or Training

  • Yale University School of Medicine, 1990


  • University of Pennsylvania School of Medicine, Neurology, PA, 1994


  • Movement Disorders, University of Pennsylvania School of Medicine, 1997

Board Certification

  • Neurology

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