Andrew Tidball, PhD

Research Investigator

Biography

Andrew M. Tidball, PhD, is a Research Investigator in the Department of Neurology in the University of Michigan Medical School. Dr. Tidball began as a postdoctoral fellow at the University of Michigan in 2014. He was promoted to Research Investigator in 2019.

After completing his undergraduate degree in biochemistry at Calvin College, Dr. Tidball earned his doctoral degree in Neuroscience from Vanderbilt University in 2014 in the lab of Dr. Aaron Bowman studying potential environmental influence of metal ion exposure in both Huntington and Parkinson diseases. He completed his postdoctoral training in the lab of Dr. Jack Parent at the University of Michigan in 2019 studying the mechanisms of genetic epilepsies.

Dr. Tidball’s research has centered around utilizing human induced pluripotent stem cells to study neurological diseases. His current research focus is to understand the mechanisms of malformations of human brain development, including anencephaly, hemimegaloencephaly, and focal cortical dysplasia. Dozens of potentially causative de novo mutations (DNMs) have recently been identified for each of these conditions due to advances in sequencing technology. His research seeks to provide evidence for the causality of these genetic variants and understanding for the mechanisms by which they cause brain malformations. He is also interested in the mechanisms of neuro-teratogens, compounds that disrupt development of the central nervous system when ingested by the mother. For all of these studies, he employs human induced pluripotent stem cells and brain organoids combined with CRISPR gene-editing and transcriptional interference.

Dr. Tidball is a member of the American Epilepsy Society, The Society for Brain Defects Research and Prevention, and International Society for Stem Cell Research. His work has been supported by the National Institute for Neurological Diseases and Stroke (NIH), the American Epilepsy Society, and Wishes for Elliott: Advancing SCN8A Research.

Areas of Interest

Research: Understanding the genetics and mechanisms of human brain malformations. Understanding the mechanisms of compounds and genetic variants associated with neural tube defects.

Credentials

Undergraduate

  • Calvin College, BS Biochemistry (ACS Certified) 2004-2008

Graduate

  • Vanderbilt University, PhD Neuroscience, 2008-2014

Postdoctoral fellowship

  • Neurology Dept., University of Michigan Health System, 2014-2019