Areas of Interest
My research focuses on metabolic crosstalk via secreted factors. Cells and tissues do not exist in isolation in the body; instead, they are constantly exposed to the flow of hormones and released factors that serve as metabolic signals. By discovering new secreted hormones, we illustrate the concept that a distributed endocrine signaling network serves important functions in the regulation of metabolic physiology and homeostasis. We combine global profiling and single-cell analysis to identify novel ligands and receptors, investigate their role in metabolic crosstalk and explore the potential of developing biologic therapeutics for the treatment of metabolic diseases.