Dr. Brooks received her B.S.E. in Engineering Science from the University of Michigan and then pursued graduate studies in Biomedical Engineering also at the University of Michigan. Following postdoctoral studies at the Institute of Gerontology, she joined the faculty in Physiology. In addition to her primary appointment in the Department of Molecular and Integrative Physiology, she holds a joint appointment the Department of Biomedical Engineering.
Areas of Interest
My research spans the organism, tissue, cellular and molecular levels and typically combines in vivo and in vitro approaches to investigate the impact of aging, exercise, disease, and changes in loading environment on structure-function relationships in skeletal muscle and tendon. A decrease with aging in muscle mass results from a loss of muscle fibers due to a loss of motor units. In addition to the muscle atrophy, unexplained muscle weakness remains when force is normalized by muscle cross-sectional area. The cellular and molecular mechanisms underlying muscle atrophy and weakness are studied in aging rodents. The mechanisms underlying differences in susceptibility to injury of muscles and tendons are also under active investigation. Exercise-induced skeletal muscle injury is initiated by the mechanical disruption of the muscle fiber ultrastructure. The initial mechanical damage initiates a cascade of events including an inflammatory response and degeneration of the damaged fibers. Understanding the tissue, cellular, and molecular adaptations responsible for the protection from injury provided by exercise training, especially the role of inflammation in initiating protective adaptations, is of particular interest.
Honors & Awards
- University of Michigan School of Medicine, Endowment for the Basic Sciences Teaching Award
- Lydia Adams Dewitt Research Award
- Brookdale Foundation National Fellowship
- Cindy Yoder Research Award for Biology and Engineering
- Elected Fellow of the American Association for the Advancement of Science
- Ph.D. University of Michigan, 1992
Published Articles or Reviews
- Brown LA, Macpherson PC, Koch LG, Qi NR, Britton SL, Brooks SV. Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. Experimental Gerontology 2019 Oct 1;125:110657. PMCID: PMC6707857
- Shcherbina A, Larouche J, Fraczek P, Yang BA, Brown LA, Markworth JF, Chung CH, Khaliq M, de Silva K, Choi JJ, Fallahi-Sichani M, Chandrasekaran S, Jang YC, Brooks SV, Aguilar CA. Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis. Cell Reports. 2020 Jul 28;32(4):107964. PMID: 32726628
- Brown LA, Guzman SD, Brooks SV. Emerging molecular mediators and targets for age-related skeletal muscle atrophy. Translational Research. 2020 Jul;221:44-57. PMID: 32243876
- Markworth JF, Brown LA, Lim E, Floyd C, Larouche J, Castor-Macias JA, Sugg KB, Sarver DC, Macpherson PC, Davis C, Aguilar CA, Maddipati KR, Brooks SV. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells. JCI Insight 2020 Sep 17;5(18):e137713. PMCID: PMC7526543
- Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H. Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 2020 Oct;19(10):e13225. PMCID: PMC7576239