Areas of Interest
I am a post-doctoral fellow in the laboratory of Dr. Ormond MacDougald. My work focuses on the disease Familial Partial Lipodystrophy Type 2 (FPLD2). FPLD2 is caused by mutation in the gene LMNA, which encodes for the nuclear filament proteins Lamin-A/C. Patients with FPLD2 lose their adipose tissue following puberty and experience severe metabolic complications including insulin resistance and leptin deficiency. My long-term goal is to use a combination of human studies and mouse models to better understand and treat this disease.
Honors & Awards
- F31 Ruth L. Kirschstein Predoctoral Individual National Research Service Award
- T32 Basic Diabetes Research Training Grant. Outstanding Oral Presentation, Southeastern Michigan Postdoctoral Symposium
- F32 Ruth L. Kirschstein Postdoctoral Individual National Research Service Award.
Credentials
- PhD in Biochemistry from The Medical College of Wisconsin
Published Articles or Reviews
- Kartz, Gabriella A, Holme, Rebecca L, Nicholson, Kay, and Sahoo, Daisy. SR-BI/CD36 Chimeric Receptors Define Extracellular Subdomains of SR-BI Critical for Cholesterol Transport. (2014) Biochemistry. 53:6173-6182. PMC4188264.
- Chadwick, Alexandra C, Holme, Rebecca L, Chen, Yiliang, Thomas, Michael J, Sorci-Thomas, Mary G, Silverstein, Roy L, Pritchard, Kirkwood A, and Sahoo, Daisy. Acrolein Impairs the Athero-protective Cholesterol Transport Functions of High Density Lipoproteins. (2015) PLoS One10:e0123138.PMC4388475.
- Holme, Rebecca L, Miller, James J, Nicholson, Kay, and Sahoo, Daisy. Tryptophan 415 is Critical for the Cholesterol Transport Functions of Scavenger Receptor BI. (2016) Biochemistry 55:103-13.PMC5428993.
- Afolayan, Adeleye J., Alexander, Maxwell, Holme, Rebecca L, Michalkiewicz, Teresa, Rana, Ujala, Teng, Ru-Jeng, Sahoo, Daisy, Pritchard, Kirkwood Jr, Konduri, Girija G. Domain Mapping of Heat Shock Protein 70 Reveals That Glutamic Acid 446 and Arginine 447 Are Critical for Regulating Superoxide Dismutase 2 Function.(2017) J. Biol. Chem. 292: 2369-2378. PMC5313107.
- Schill, Rebecca L., Knaack, Darcy A., Powers, Hayley R., Chen, Yiliang, Yang, Moua, Schill, Daniel J., Silverstein, Roy L., and Sahoo, Daisy. Modification of HDL by Reactive Aldehydes Alters Select Cardio-Protective Functions of HDL in Macrophages. (2019) F.E.B.S J. PMID: 31386799.
- Xu, Hao., Kaul, Sushma, Kallinger, Rachel, Thomas, Michael. J., Schill, Rebecca L., Sahoo, Daisy, and Sorci-Thomas, Mary G. PCPE2 and SR-BI Partner to Impact Accumulation of Fat in Mice. (2021) Under Revision.
- Chen, Noah, Schill, Rebecca L., O’Donnell, Michael, Xu, Kevin, MacDougald, Ormond A., Koenig, Ronald J., and Xu, Bin. Novel role of the transcription factor Nkx1-2 in the regulation of adipogenesis. (2019). J. Biol. Chem. PMID: 31615896.
- Li, Ziru, Hardij, Julie, Evers, Simon S., Hutch, Chelsea R., Choi, Sarah M., Shao, Yikai, Learman, Brian S., Lewis, Kenneth T., Schill, Rebecca L., Mori, Hiroyuki, Corsa, Callie A., Bagchi, Devika P., Romanelli, Steven M., Kim Ki-Suk., Griffin, Cameron, Seeley, Randy J.,Singer, Kanakadurga, Sandoval, Darleen A., Rosen, Clifford J., and MacDougald, Ormond A. G-CSF Partially Mediates Effects of Sleeve Gastrectomy on the Bone Marrow Niche. (2019).JCI.6: 130. PMID: 31063988.
- Bagchi, Devika P., Corsa, Callie A., Hardij, Julie, Mori, Hiroyuki, Learman, Brian S., Lewis, Kenneth T., Schill, Rebecca L.,Romanelli, Steven M., and MacDougald, Ormond A., Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction (2020). Molecular Metabolism. PMID: 32325263.