Louis G. D'Alecy, DMD, PhD

Preventive and therapeutic interventions are pursued as well as basic mechanisms of cell damage. Whole animal studies using either anesthetized or conscious preparations are complemented by in vitro preparations, where appropriate, to test physiologically important hypotheses. Systemic hypoxia, regional ischemia and cardiac arrest/resuscitation models, in mice, rats and dogs are used sequentially and simultaneously to acquire data relevant to the resolution of clinical problems. Undergraduate, graduate, medical, and postdoctoral participation is encouraged at all levels of laboratory activity.  Current projects involve HPLC analysis of endogenous NOS inhibitors involved in endothelial dysfunction.  Accumulation of NOS inhibitors in stored blood used for transfusion suggests one mechanism for adverse responses to blood transfusion and possible therapeutic compensations.