Costas Lyssiotis

Costas A. Lyssiotis, PhD

Maisel Research Professor of Oncology
Associate Professor of Molecular & Integrative Physiology
Associate Professor of Internal Medicine
Director Graduate Program in Cancer Biology

Rogel Cancer Center
1150 E. Medical Center Drive, Room 6308
Ann Arbor, MI 48109-5942



Prof. Lyssiotis obtained his bachelor’s degree in Chemistry and Biochemistry from the University of Michigan in 2004, his PhD in Chemical Biology from The Scripps Research Institute in 2010, and then completed postdoctoral training in the laboratory of Lewis C. Cantley at Harvard and Cornell. In 2015, Prof. Lyssiotis joined the faculty at the University of Michigan with appointments in the Departments of Physiology and Medicine. His lab studies the biochemical pathways and metabolic requirements that enable tumor survival and growth. This work spans the areas of cancer metabolism, the tumor microenvironment and immunometabolism using and developing protocols in mass spectrometry-based metabolomics. Ultimately, his group aims to transition new information about these processes into targeted therapies for cancer and other diseases. He is the recipient of several junior scholar awards including being named a Lefkofsky Scholar, a Kimmel Scholar, an AACR NextGen young investigator, a Dale F. Frey Breakthrough Scientist, and a V Foundation Fellow.

Areas of Interest

Tumor Metabolism, Cancer Biochemistry, Immunometabolism, Tumor Microenvironment, Pancreatic Cancer, Metabolomics, Immunotherapy, Cancer-Diet Interactions, Diffuse Intrinsic Pontine Glioma (DIPG)

Honors & Awards

  • 2019 - Young Investigator Award (Basic Science), American Gastroenterological Association
  • 2019 - Cancer Research Scholar Award, American Cancer Society
  • 2017 -  NextGen Young Investigator Award, American Association for Cancer Research
  • 2017 -  GI and Liver Physiology New Investigator Award, American Physiological Society
  • 2016 -  Melanoma Research Alliance Young Investigator
  • 2016 -  The V Foundation Junior Scholar Award
  • 2016 -  Sidney Kimmel Foundation Scholar
  • 2016 -  Lefkofsky Family Foundation Scholar
  • 2015 -  Tri-Institutional Breakout Prize for Junior Investigators
  • 2015 -  Dale Frey Award for Breakthrough Scientists, Damon Runyon Cancer Research Foundation


  • Postdoctoral Fellowship, Harvard Medical School
  • PhD, Chemical Biology, The Scripps Research Institute
  • BS, Chemistry and Biochemistry, University of Michigan - Ann Arbor

Published Articles or Reviews

  • Halbrook CJ, Pontious C, Lee H-J, Kovalenko I, Zhang Y, Lapienyte L, Dreyer S, Kremer DL, Zhang L, Sajjakulnukit P, Zhang L, Nelson B, Hong H, Kemp S, Chang D, Biankin A, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA. Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metabolism, 2019;29:1390-1399.
  • Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, †Lyssiotis CA [co-senior authors], †Kimmelman AC. Pancreatic Stellate Cells Support Tumor Metabolism Through Autophagic Alanine Secretion. Nature 2016;536:479–483.
  • Lee H-J, Kremer DM, Sajjakulnukit P, Zhang L, Lyssiotis CA. Meta-analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics. Metabolomics, 2019.
  • Halbrook C, Lyssiotis CA. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. Cancer Cell 2017;31:5–19.

Full list:

Web Sites