Understanding the role of Schwann cells in prediabetic and diabetic neuropathy
Dr. Stephanie Eid has served as a diabetes team leader for the NeuroNetwork for Emerging Therapies since January 2019. Her current efforts are focused on exploring how Schwann cells, the supporting cells of peripheral nerves, maintain the health of nerve axons (thread-like structures attached to a nerve cell and send out signals) under normal conditions and promote damage in prediabetic and diabetic neuropathy. She is particularly interested in the role of extracellular vesicles and miRNAs in regulating nerve metabolism and function with or without exercise and dietary interventions. These innovative studies will advance our understanding of prediabetic and diabetic neuropathy and help develop novel Schwann cell-specific targets for neuropathy treatment.
Credentials
- BS/MS, Physiology, American University of Beirut, 2012
- PhD, Neuroscience, American University of Beirut/Paris Descartes University, Sorbonne Paris Cité, 2017
Honors & Awards
- Wolfe Neuropathy Research Prize, American Neurological Association
- The Angelika Bierhaus Prize in basic research, Neurodiab (diabetic neuropathy study group of the European Association for the Study of Diabetes)
- National Council for Scientific Research – Lebanon Fellowship
- Training Scholarship, Paris Descartes University
- Travel grant, Peripheral Nerve Society
- Travel grant, National Institute of Diabetes and Digestive and Kidney Diseases
Top Publications
Eid SA, Feldman EL. Advances in Diet-Induced Rodent Models of Metabolically Acquired Peripheral Neuropathy. Dis Model Mech. In press.
Eid S*, Hinder LM*, Zhang H*, Eksi R, Nair V, Eddy S, Eichinger F, Park M, Saha J, Berthier CC, Jagadish HV, Guan Y, Pennathur S, Hur J, Kretzler M, Feldman EL, Brosius FC. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: predictors of pathology and RAAS blockade effects. FASEB J. 35(5):e21467, 2021.
*The authors contributed equally to this work
Eid S*, Guo K*, Elzinga SE*, Pacut C, Feldman EL, and Hur J. Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes of Human Diabetic Neuropathy. Clin Epigenet. 2020, 12, 123.
*The authors contributed equally to this work
Eid SA, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, Barakat R, Boutary S, Chanal J, Aractingi S, Wiesel P, Szyndralewiez C, Azar ST, Boitard C, Zaatari G, Eid AA*, Massaad C*. Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice. Diabetes. 2020, 69(3): 448-464.
Eid SA*, O'Brien PD*, Guo K*, Rumora AE*, Hinder LM*, Hayes JM, Mendelson FE, Hur J, Feldman EL. Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes. Dis Model Mech. 2020, 13(2).
*The authors contributed equally to this work
News
Dr. Eid Wins International Diabetes Research Award
Stephanie Eid, Ph.D., added to her growing accolades with the Peter J. Dyck Award for Diabetes Research by the Peripheral Nerve Society (PNS), one of the most prestigious international awards for early career researchers in the field of neuropathy.
Neuropathy's New Hope in Genetics
Funded by Michigan Medicine’s own Department of Neurology, a new grant will seek to give diabetic neuropathy patients new hope as it looks into how a particular gene affects the condition.
Grant to Uncover Therapy Targets for Diabetic Neuropathy
Stephanie Eid, Ph.D., received a Pilot/Feasibility Grant from the Michigan Diabetes Research Center to investigate Schwann cells and extracellular vesicles under healthy and disease conditions. If successful, these findings will lead to new therapeutic targets for diabetic neuropathy, which right now has no effective treatments.
ANA Announces Dr. Stephanie Eid as Winner of the Wolfe Neuropathy Research Prize
The Rose C. and Nathan L. Milstein Family Emerging Scholar will be presented with the award at the American Neurological Association's Annual Meeting in Chicago this October.
Dr. Stephanie Eid Receives Prestigious International Award
At the 31st Annual Meeting of NEURODIAB, Dr. Stephanie Eid was awarded the Angelika Bierhaus prize in basic research .
Dr. Stephanie Eid Chosen for NeuroDiab Discovery Team
NeuroNetwork team member offers the first article for the international group of promising young scientists that publishes the latest news and research for the diabetic neuropathy community.