Understanding how the immune system affects Alzheimer's disease
Rosie Henn is examining how a high-fat diet can affect the immune system and lead to brain inflammation. Her current research is using animal models that are fed increased amounts of fat to see how it activates microglia cells. Microglia are immune system cells that normally protect neurons in the brain and enable healthy communication between neurons. Microglia malfunction in AD brains may contribute to cognitive impairment.
For her residency, Henn plans to pursue a path in adult neurology.
- BA, Biology (neural and behavioral science), Haverford College, 2013
Honors & Awards
- Student chapter executive board member of the American Academy of Developmental Medicine and Dentistry, 2016-
- MedStart/Child Advocacy Seminar Co-President, 2016-17
Kim, B., Elzinga, S.E., Henn, R.E., McGinley, L.M., and Feldman, E.L. (2019). The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer’s disease. Neurobiol. Dis. 132. 10.1016/J.NBD.2019.104541.
Henn, R.E.*, Noureldein, M.H.*, Elzinga, S.E.*, Kim, B., Savelieff, M.G., and Feldman, E.L. (2022). Glial-neuron crosstalk in health and disease: A focus on metabolism, obesity, and cognitive impairment. Neurobiol. Dis. 170, 105766. 10.1016/J.NBD.2022.105766
Elzinga, S.E., Henn, R., Murdock, B.J., Kim, B., Hayes, J.M., Mendelson, F., Webber-Davis, I., Teener, S., Pacut, C., Lentz, S.I., et al. (2022). cGAS/STING and innate brain inflammation following acute high-fat feeding. Front. Immunol. 13. 10.3389/FIMMU.2022.1012594.
Henn, R.E.*, Elzinga, S.E.*, Glass, E., Parent, R., Guo, K., Allouch, A.A., Mendelson, F.E., Hayes, J., Webber-Davis, I., Murphy, G.G., et al. (2022). Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice. Immun. Ageing 19. 10.1186/S12979-022-00323-7.
Henn, R.E., Guo, K., Elzinga, S.E., Noureldein, M.H., Mendelson, F.E., Hayes, J.M., Rigan, D.M., Savelieff, M.G., Hur, J., and Feldman, E.L. (2023). Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity. iScience 26. 10.1016/J.ISCI.2023.106164.