Sheryl Smith - [email protected]
Dr. Moore obtained her B.A. in Microbiology from the University of Texas at Austin and her PhD in Immunology from the University of Texas Southwestern Medical Center. Her postdoctoral training was at U.T. Southwestern and Stanford University prior to starting her faculty career at Michigan.
Areas of Interest
Dr. Moore’s laboratory has several areas of research interest. One focus is the regulation of innate and adaptive immunity post-stem cell transplantation. Her laboratory uses murine models and human clinical samples to study alterations to dendritic cell function, Th1 vs Th17 skewing in response to herpesvirus infections, the role of IL-17 in development of pneumonitis and fibrosis and how viral infections impact development of graft versus host disease. For this work she focuses on murine herpesviruses. Her laboratory is also interested in how the process of transplantation alters innate immune cell function to impair clearance of bacterial lung infections.
She has active projects related to secondary bacterial infection in the lung following influenza or respiratory syncytial virus infection. The influenza project focuses on TLR9 signaling and how the innate immune response is altered in the presence of influenza infection. The RSV project seeks to understand impaired neutrophil recruitment in response to bacterial challenge.
Another area of interest is the pathogenesis of pulmonary fibrosis. In this work, her laboratory has studied how development of fibrosis in the lungs alters lung microbiota, how herpesvirus infections exacerbate fibrosis and how monocyte/macrophages impact development of disease. Current projects are focused on the role of myeloid versus epithelial derived HB-EGF in driving disease pathogenesis. She also studies how the fibrotic lung milieu impacts the function of innate immune cells to clear bacterial infections.
Finally, her laboratory has active collaborations with Dr. Katherine Gallagher to study diabetic wound healing. In this work they are interested in prostaglandin signaling and epigenetic alterations to inflammatory macrophages that influence wound healing. In collaborative projects with Durga Singer, we are studying how diabetic mice are impaired in clearance of bacterial pneumonia. We also study influenza and coronavirus infections in the setting of diabetes.
Honors & Awards
2021 Elizabeth A. Rich award (American Thoracic Society)
2020 Named Nancy Williams Walls Professor
2019 Rackham Distinguished Graduate Mentoring Award
2018 American Thoracic Society Fellow (ATSF; inaugural class)
2017 Named Galen B. Toews Collegiate Professor
2014 Inducted into the U-M League of Research Excellence
2014 American Thoracic Society Recognition Award for Scientific Accomplishments
2011 Distinguished Alumnus, Immunology Graduate Program, U.T. Southwestern
NIH R35, R01, T32