Clinical Research

Rodica Pop-Busui, MD, PhD

“This year has showcased the many strengths of the Department of Internal Medicine and the immense value of our missions of research, education and patient care. Through our creativity, innovation, dedication, and teamwork, we were able to mobilize and provide vital care on the frontlines while continuing to pursue new answers and solutions that will make a difference for many in the future.” - Rodica Pop-Busui, MD, PhDLearn more about Dr. Pop-Busui.

Clinical & Health Services Research Connection

Internal Medicine has a sizable and accomplished history in health services research. Researchers from our department make up the largest group within U-M’s Institute for Healthcare Policy & Innovation (IHPI). Because our health services research footprint is so vast, we have the perfect opportunity to stimulate the development of clinical research projects that address pressing topics already being investigated by our IHPI colleagues, from healthy aging to the opioid epidemic. As our clinical trialists identify effective interventions, our outcomes researchers can examine them in clinical practice. And if an intervention falls short in practice, our trialists can compare alternatives. With our health services and clinical researchers working together, we can make quicker advancements to improve patient care.

The Clinical Trials Academy, offered jointly by the Department of Internal Medicine and the Medical School, is a hands-on training program in clinical research and clinical trial design.

The Clinical Research Spotlight shines a light on faculty members who are advancing clinical research here at Michigan Medicine and around the globe. Learn more.

The Department of Internal Medicine’s Early Career Faculty/Investigator Forum is an interactive tool designed to increase awareness about a broad range of science discoveries within our department and institution that could be relevant to young investigators, facilitate connecting with other faculty and scientists with complementary interests, help to direct questions or concerns related to clinical translational research, and provide an easier access/link to the rest of the available resources related to clinical research.

The ultimate goals are to help early career faculty/investigators build a successful research program, advance collaborative team science efforts across our department and institution that will bring to trial new molecules pathways that are being identified by our basic scientists, and enhance our department leadership in clinical research nationwide.

Funded by the National Institutes of Health, Michigan Medicine and five other U.S. research institutions launch the first-ever multicenter network to study diabetic foot ulcers. Learn more.

Michigan Medicine launch two new clinics aimed at treating and studying COVID-19's long-term outcomes in vulnerable adult and pediatric populations. Read more.

The Michigan Medicine/Peking University Health Science Center (PKUHSC) Joint Institute for Translational and Clinical Research funded 10 projects for 2021, 5 of which were co-led by Department of Internal Medicine researchers. Learn more.

Older Adults with Rheumatoid Arthritis Still Undermedicated, Despite Aggressive Guidelines

Jiha Lee, MD, MHS and team find that while prescription rates for disease-modifying drugs have improved, there is more work to be done to ensure older adults are on optimized treatment. Read more.

High Blood Sugar and suPAR Levels Independently Worsen COVID-19 Outcomes

Salim Hayek, MD; Matthias Kretzler, MD; Rodica Pop-Busui, MD, PhD; and team investigate the role of inflammatory biomarkers in hospitalized COVID patients and uncover risk factors for worse health outcomes in those with diabetes. Read more.

Half of Older Adults Now Die with a Dementia Diagnosis

Julie Bynum, MD, MPH finds that nearly half of all older adults now die with a diagnosis of dementia listed on their medical record, up 36% from two decades ago. Read more.

Racial and Ethnic Disparities Exist in Prescribing Rifaximin for Patients with Hepatic Encephalopathy

Elliot Tapper, MD; Neehar Parikh, MD, MS; and team find that Black Americans experience significant health inequities when receiving treatment for this cirrhosis-related disorder. Read more.

Medicaid Health Plan Community Health Workers Have Positive Impact on Care

Michele Heisler, MD, MPA and team show that emergency care and costs went down, while outpatient care went up, among low-income Detroit residents who connected with a community health worker. Read more.