Basic Research

The University of Michigan Lupus Program has a strong program in basic science research. Areas of research include:

  • Identifying genetic and epigenetic abnormalities in lupus patients that predispose them to the disease.
  • T cell abnormalities in lupus.
  • Abnormal cell death and the development of lupus.
  • Abnormalities in the interactions of different cells of the immune system that might predispose lupus patients to the disease.
  • Mechanisms by which lupus patients develop accelerated heart disease.
  • Mechanisms of kidney damage in lupus.
  • Role of dendritic cells and neutrophils in lupus.
  • Abnormal signal transduction in lupus cells.