Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19

New research led by the Knight lab, Prothrombotic Autoantibodies in Serum from Patients Hospitalized with COVID-19, published in Science Translational Medicine on November 2, is featured in over 95 news outlets.

More Highlights

Endoplasmic Reticulum Stress Sensor IRE1α Propels Neutrophil Hyperactivity in Lupus
Gautam Sule, Basel H. Abuaita, Paul A. Steffes, Andrew T. Fernandes, Shanea K. Estes, Craig J. Dobry, Deepika Pandian, Johann E. Gudjonsson, J. Michelle Kahlenberg, Mary X. O'Riordan, Jason S. Knight. The Journal of Clinical Investigation. 2021 Feb 9

Anti-Neutrophil Properties of Natural Gingerols in Models of Lupus
Ramadan A. Ali, Alex A. Gandhi, Lipeng Dai, Julia K. Weiner, Shanea K. Estes, Srilakshmi Yalavarthi, Kelsey Gockman, Duxin Sun, Jason S. Knight. JCI Insight. 2020 Dec 29

Neutrophil Extracellular Traps and Thrombosis in COVID-19
Zuo Y, Zuo M, Yalavarthi S, Gockman K, Madison JA, Shi H, Woodard W, Lezak SP, Lugogo NL, Knight JS, Kanthi Y. Journal of Thrombosis and Thrombolysis. 2020 Nov 5

Neutrophil Calprotectin Identifies Severe Pulmonary Disease in COVID-19
Shi H, Zuo Y, Yalavarthi S, Gockman K, Zuo M, Madison JA, Blair C, Woodward W, Lezak SP, Lugogo NL, Woods RJ, Lood C, Knight JS, Kanthi Y. Journal of Leukocyte Biology. 2020 Sep 1

Anti-NET Antibodies and Impaired NET Degradation in Antiphospholipid Syndrome
Zuo Y, Yalavarthi S, Gockman K, Madison JA, Gudjonsson JE, Kahlenberg JM, McCune WJ, Bockenstedt PL, Karp DR, Knight JS. Arthritis & Rheumatoly. 2020 Jul 30

New (Re)Purpose for an Old Drug: Purinergic Modulation May Extinguish the COVID-19 Thromboinflammatory Firestorm
Kanthi Y, Knight JS, Zuo Y, Pinsky DJ. JCI Insight. 2020 June 12

Neutrophil Extracellular Traps in COVID-19
Yu Zuo, Srilakshmi Yalavarthi, Hui Shi, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Christopher N. Blair, Andrew Weber, Betsy J. Barnes, Mikala Egeblad, Robert J. Woods, Yogendra Kanthi, and Jason S. Knight. JCI Insight. 2020 April 24

Increased Adhesive Potential of Antiphospholipid Syndrome Neutrophils Mediated by Beta‐2 Integrin Mac‐1
Sule G, Kelley WJ, Gockman K, Yalavarthi S, Vreede AP, Banka AL, Bockenstedt PL, Eniola-Adefeso O, Knight JS. Arthritis Rheumatol. 2019 Jul 28

Adenosine Receptor Agonism Protects Against NETosis and Thrombosis in Antiphospholipid Syndrome
Ali, Ramadan A., Gandhi, Alex A., Meng, He, Yalavarthi, Srilakshmi, Vreede, Andrew P., Estes, Shanea K., Palmer, Olivia R., Bockenstedt, Paula L., Pinsky, David J., Greve, Joan M., Diaz, Jose A., Kanthi, Yogendra, Knight, Jason S. Nature Communications. 2019 April 23

Ectonucleotidase-Mediated Suppression of Lupus Autoimmunity and Vascular Dysfunction
Knight JS, Mazza LF, Yalavarthi S, Sule G, Ali RA, Hodgin JB, Kanthi Y, Pinsky DJ. Front Immunol. 2018 Jun 11;9:1322

Activated Signature of Antiphospholipid Syndrome Neutrophils Reveals Potential
Therapeutic Target

Knight JS, Meng H, Coit P, Yalavarthi S, Sule G, Gandhi AA, Grenn RC, Mazza LF, Ali RA, Renauer P, Wren JD, Bockenstedt PL, Wang H, Eitzman DT, Sawalha AH. JCI Insight. 2017 Sep 21;2(18). pii: 93897

In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis
Meng H, Yalavarthi S, Kanthi Y, Mazza LF, Elfline MA, Luke CE, Pinsky DJ, Henke PK, Knight JS. Arthritis Rheumatol. 2017 Mar;69(3):655-667

Endothelial Progenitor Dysfunction Associates with a Type I Interferon Signature in Primary Antiphospholipid Syndrome
Grenn RC, Yalavarthi S, Gandhi AA, Kazzaz NM, Núñez-Álvarez C, Hernández-Ramírez D, Cabral AR, McCune WJ, Bockenstedt PL, Knight JS. Ann Rheum Dis. 2017 Feb;76(2):450-457

Release of Neutrophil Extracellular Traps by Neutrophils Stimulated with Antiphospholipid Antibodies: A Newly Identified Mechanism of Thrombosis in the Antiphospholipid Syndrome
Yalavarthi S, Gould TJ, Rao AN, Mazza LF, Morris AE, Núñez-Álvarez C, Hernández-Ramírez D, Bockenstedt PL, Liaw PC, Cabral AR, Knight JS. Arthritis Rheumatol. 2015 Nov;67(11):2990-3003