Translational research centered on understanding the developmental origin of pubertal and adult reproductive and metabolic disorders. Specifically, our studies focus on the impact of maternal exposure to native steroids (testosterone, estradiol) and environmental endocrine disrupting pollutants such as bisphenol-A and phthalates in altering developmental trajectory of fetus and programming adult diseases. Utilizing integrative approaches ranging from cell and molecular biology as well as in vitro systems to whole animal physiology and human translation we seek to understand the mechanisms by which native and environmental steroids program reproductive neuroendocrine, ovarian and metabolic defects such as that seen in hyperandrogenic disorders like Poly Cystic Ovarian Syndrome (PCOS) and identify prevention and treatment strategies.
Vasantha Padmanabhan, PhD, MS
Professor Emerita of Pediatrics
Professor Emerita of Molecular and Integrative Physiology
Professor Emerita of Environmental Health Sciences
Professor Emerita in Service
Professor Emerita of Obstetrics and Gynecology
Countries of Interest: Argentina, Brazil, Chile, China, India