Chase A Weidmann
Assistant Professor of Biological Chemistry
[email protected]

Available to mentor
Chase A Weidmann
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • Postdoctoral Scholar/Staff Scientist
      Washington University in St. Louis School of Medicine, Cell Biology and Physiology, 2021
    • Postdoctoral Fellow
      University of North Carolina at Chapel Hill, Chemistry, 2020
    • Ph.D. in Biological Chemistry
      University of Michigan, Ann Arbor, MI, 2015
    • B.S. in Biochemistry
      University of Rochester, Rochester, NY, 2009
    Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Rogel Cancer Center
    Research Overview

    We are interested in how cellular signals are propagated through interactions between RNA and protein, and how these interaction networks malfunction during cancer and disease. While most of the human genome is transcribed into RNA, only a small portion (< 5%) encodes protein; the remainder of the transcriptome includes many classes of small and large noncoding RNAs whose mechanisms are not fully understood. Our vision is to leverage RNA and protein sequencing and imaging technologies to characterize RNA-protein interaction networks and generate novel therapeutic strategies that target protein interaction sites on RNA.

    Links
    • Website
    Recent Publications See All Publications
    • Journal Article
      Measuring Proximity-Mediated Function of mRNA Regulatory Proteins by Engineered Tethering.
      Hatfield BM, Weidmann CA, Weeks KM. Methods Mol Biol, 2024 2723: 143 - 159. DOI:10.1007/978-1-0716-3481-3_9
      PMID: 37824069
    • Journal Article
      Structural analysis of MALAT1 long noncoding RNA in cells and in evolution.
      Monroy-Eklund A, Taylor C, Weidmann CA, Burch C, Laederach A. RNA, 2023 May; 29 (5): 691 - 704. DOI:10.1261/rna.079388.122
      PMID: 36792358
    • Journal Article
      Single-Molecule Correlated Chemical Probing: A Revolution in RNA Structure Analysis.
      Mustoe AM, Weidmann CA, Weeks KM. Acc Chem Res, 2023 Apr 4; 56 (7): 763 - 775. DOI:10.1021/acs.accounts.2c00782
      PMID: 36917683
    • Journal Article
      Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA.
      Grayeski PJ, Weidmann CA, Kumar J, Lackey L, Mustoe AM, Busan S, Laederach A, Weeks KM. Nucleic Acids Res, 2022 Sep 23; 50 (17): 9689 - 9704. DOI:10.1093/nar/gkac739
      PMID: 36107773
    • Journal Article
      Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP.
      Olson SW, Turner A-MW, Arney JW, Saleem I, Weidmann CA, Margolis DM, Weeks KM, Mustoe AM. Mol Cell, 2022 May 5; 82 (9): 1708 - 1723.e10. DOI:10.1016/j.molcel.2022.02.009
      PMID: 35320755
    • Journal Article
      Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors.
      Przanowska RK, Weidmann CA, Saha S, Cichewicz MA, Jensen KN, Przanowski P, Irving PS, Janes KA, Guertin MJ, Weeks KM, Dutta A. Cell Rep, 2022 Feb 15; 38 (7): 110361 DOI:10.1016/j.celrep.2022.110361
      PMID: 35172143
    • Journal Article
      Analysis of RNA-protein networks with RNP-MaP defines functional hubs on RNA.
      Weidmann CA, Mustoe AM, Jariwala PB, Calabrese JM, Weeks KM. Nat Biotechnol, 2021 Mar; 39 (3): 347 - 356. DOI:10.1038/s41587-020-0709-7
      PMID: 33077962
    • Journal Article
      Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid.
      Iserman C, Roden CA, Boerneke MA, Sealfon RSG, McLaughlin GA, Jungreis I, Fritch EJ, Hou YJ, Ekena J, Weidmann CA, Theesfeld CL, Kellis M, Troyanskaya OG, Baric RS, Sheahan TP, Weeks KM, Gladfelter AS. Mol Cell, 2020 Dec 17; 80 (6): 1078 - 1091.e6. DOI:10.1016/j.molcel.2020.11.041
      PMID: 33290746