Olesya Plazyo, PhD
Research Investigator
Dermatology
[email protected]

Available to mentor
Olesya Plazyo, PhD
Research Investigator
  • About
  • Qualifications
  • Center Memberships
  • Recent Publications
    • About

    Olesya Plazyo, PhD, joined the U-M Department of Dermatology faculty as a Research Investigator in the fall of 2021. She is a member of the Autoimmunity/Immunogenetics in Skin Research Program in the laboratory of Dr. Johann Gudjonsson. Dr. Plazyo is pursuing research focused on deciphering the molecular mechanisms of autoimmune and autoinflammatory diseases affecting skin and beyond, with a special focus on sexual dimorphism in immune response.

    Dr. Plazyo received her PhD in Physiology, with a concentration in reproductive immunology, from the NICHD Perinatology Research Branch and Wayne State University School of Medicine. She completed post doctoral training in cellular cardiology and immunology at Wayne State University, before joining the U-M Department of Dermatology in 2019 as a postdoctoral research fellow.

    Qualifications
    • Post-doctoral Research Fellow
      University of Michigan Medical School, Dermatology, 2021
    • Post-doctoral Research Fellow
      Wayne State University, school of Medicine, 2019
    • Research Investigator
      University of Michigan Medical School, Dermatology
    • Ph.D.
      Wayne State University, Detroit, 2016
    • M.S.
      Wayne State University, Detroit, 2012
    • B.A.
      Wayne State University, Detroit, 2006
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Recent Publications See All Publications
    • Journal Article
      Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.
      Ma F, Tsou P-S, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nat Commun, 2024 Jan 3; 15 (1): 210 DOI:10.1038/s41467-023-44645-6
      PMID: 38172207
    • Journal Article
      Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
      Jiang Y, Gruszka D, Zeng C, Swindell WR, Gaskill C, Sorensen C, Brown W, Gangwar RS, Tsoi LC, Webster J, Sigurðardóttir SL, Sarkar MK, Uppala R, Kidder A, Xing X, Plazyo O, Xing E, Billi AC, Maverakis E, Kahlenberg JM, Gudjonsson JE, Ward NL. JCI Insight, 2024 Mar 12; 9 (8): DOI:10.1172/jci.insight.172764
      PMID: 38470486
    • Journal Article
      HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling.
      Uppala R, Sarkar MK, Young KZ, Ma F, Vemulapalli P, Wasikowski R, Plazyo O, Swindell WR, Maverakis E, Gharaee-Kermani M, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE. iScience, 2024 Feb 16; 27 (2): 108986 DOI:10.1016/j.isci.2024.108986
      PMID: 38327798
    • Journal Article
      Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa.
      van Straalen KR, Ma F, Tsou P-S, Plazyo O, Gharaee-Kermani M, Calbet M, Xing X, Sarkar MK, Uppala R, Harms PW, Wasikowski R, Nahlawi L, Nakamura M, Eshaq M, Wang C, Dobry C, Kozlow JH, Cherry-Bukowiec J, Brodie WD, Wolk K, Uluçkan Ö, Mattichak MN, Pellegrini M, Modlin RL, Maverakis E, Sabat R, Kahlenberg JM, Billi AC, Tsoi LC, Gudjonsson JE. J Clin Invest, 2024 Feb 1; 134 (3): DOI:10.1172/JCI169225
      PMID: 38051587
    • Preprint
      Oral Baricitinib in the Treatment of Cutaneous Lichen Planus.
      Hwang A, Kechter J, Do T, Hughes A, Zhang N, Li X, Wasikowski R, Brumfiel C, Patel M, Boudreaux B, Bhullar P, Nassir S, Yousif M, DiCaudo DJ, Fox J, Gharaee-Kermani M, Xing X, Zunich S, Branch E, Kahlenberg JM, Billi AC, Plazyo O, Tsoi LC, Pittelkow MR, Gudjonsson JE, Mangold AR. 2024 Jan 11; DOI:10.1101/2024.01.09.24300946
      PMID: 38260663
    • Journal Article
      Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab.
      Ma F, Gharaee-Kermani M, Tsoi LC, Plazyo O, Chaskar P, Harms P, Patrick MT, Xing X, Hile G, Piketty C, Lazzari A, Van Delm W, Maverakis E, Nakamura M, Modlin RL, Kahlenberg JM, Billi AC, Julia V, Krishnaswamy JK, Gudjonsson JE. J Allergy Clin Immunol, 2024 Jan; 153 (1): 146 - 160. DOI:10.1016/j.jaci.2023.07.005
      PMID: 37506977
    • Journal Article
      Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension.
      Hesson AM, Langen ES, Plazyo O, Gudjonsson JE, Ganesh SK. BMC Med Genomics, 2023 May 2; 16 (1): 91 DOI:10.1186/s12920-023-01522-x
      PMID: 37131171
    • Journal Article
      Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis.
      Ma F, Plazyo O, Billi AC, Tsoi LC, Xing X, Wasikowski R, Gharaee-Kermani M, Hile G, Jiang Y, Harms PW, Xing E, Kirma J, Xi J, Hsu J-E, Sarkar MK, Chung Y, Di Domizio J, Gilliet M, Ward NL, Maverakis E, Klechevsky E, Voorhees JJ, Elder JT, Lee JH, Kahlenberg JM, Pellegrini M, Modlin RL, Gudjonsson JE. Nat Commun, 2023 Jun 12; 14 (1): 3455 DOI:10.1038/s41467-023-39020-4
      PMID: 37308489