Available to mentor
Matthew Patrick, MEng, PhD is a Research Assistant Professor of Dermatology at the University of Michigan Medical School, and is a member of the Cutaneous Bioinformatics Research Program. Dr. Patrick is pursuing research focused upon translational bioinformatics, particularly on providing biological inference from high dimensional data for dermatological research.
Dr. Patrick received his PhD in Computer Science from University of York in the United Kingdom in 2013. He completed postdoctoral research training in Epidemiology and Modelling at the University of Cambridge before joining the U-M Department of Dermatology in 2016 as a postdoctoral research fellow working with Dr. Lam C. (Alex) Tsoi in the Cutaneous Bioinformatics Program. He joined the U-M Department of Dermatology faculty in 2020.
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Center MemberPrecision Health Initiative
- Applying mathematical, statistical and computational approaches to understand the behaviours of complex systems.
- Using advanced machine learning and optimisation techniques to address challenging problems.
- Testing and evaluating the implications of data and software quality for scientific research.
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Zhang H, Patrick MT, Tejasvi T, Sarkar MK, Wasikowski R, Stuart PE, Li Q, Xing X, Voorhees JJ, Ward NL, He K, Zhou X, Gudjonsson JE, Nair RP, Elder JT, Tsoi LC. Br J Dermatol, 2023 Dec 20; 190 (1): 70 - 79.Journal ArticleRetrospective pharmacogenetic study of psoriasis highlights the role of KLK7 in tumour necrosis factor signalling.
DOI:10.1093/bjd/ljad332 PMID: 37672660 -
Ma F, Gharaee-Kermani M, Tsoi LC, Plazyo O, Chaskar P, Harms P, Patrick MT, Xing X, Hile G, Piketty C, Lazzari A, Van Delm W, Maverakis E, Nakamura M, Modlin RL, Kahlenberg JM, Billi AC, Julia V, Krishnaswamy JK, Gudjonsson JE. J Allergy Clin Immunol, 2024 Jan; 153 (1): 146 - 160.Journal ArticleSingle-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab.
DOI:10.1016/j.jaci.2023.07.005 PMID: 37506977 -
Khunsriraksakul C, Li Q, Markus H, Patrick MT, Sauteraud R, McGuire D, Wang X, Wang C, Wang L, Chen S, Shenoy G, Li B, Zhong X, Olsen NJ, Carrel L, Tsoi LC, Jiang B, Liu DJ. Nat Commun, 2023 Feb 7; 14 (1): 668Journal ArticleMulti-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus.
DOI:10.1038/s41467-023-36306-5 PMID: 36750564 -
Patrick MT, Li Q, Ward NL, Gudjonsson JE, Elder JT, Tsoi LC. Journal of Investigative Dermatology, 2023 Nov; 143 (11): s340Journal Article44 Predicting individuals with psoriasis at risk from multiple sclerosis
DOI:10.1016/j.jid.2023.09.052 -
Wasikowski R, Patrick MT, Li Q, Nie Q, Andersen B, Plikus M, Kahlenberg JM, Billi A, Tsoi L, Gudjonsson J. Journal of Investigative Dermatology, 2023 Sep; 143 (9): b9Proceeding / Abstract / PosterLB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes
DOI:10.1016/j.jid.2023.06.043 -
Wang Y-N, Gan T, Qu S, Xu L-L, Hu Y, Liu L-J, Shi S-F, Lv J-C, Tsoi LC, Patrick MT, He K, Berthier CC, Xu H-J, Zhou X-J, Zhang H. Kidney Int, 2023 Sep; 104 (3): 562 - 576.Journal ArticleMTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
DOI:10.1016/j.kint.2023.06.018 PMID: 37414396 -
Patrick MT, Nair RP, He K, Stuart PE, Billi AC, Zhou X, Gudjonsson JE, Oksenberg JR, Elder JT, Tsoi LC. Ann Neurol, 2023 Aug; 94 (2): 384 - 397.Journal ArticleShared Genetic Risk Factors for Multiple Sclerosis/Psoriasis Suggest Involvement of Interleukin-17 and Janus Kinase-Signal Transducers and Activators of Transcription Signaling.
DOI:10.1002/ana.26672 PMID: 37127916 -
Zhang H, Patrick MT, Sarkar M, White BEP, Uppala R, He K, Elder JT, Zhou X, Gudjonsson J, Tsoi LC. Journal of Investigative Dermatology, 2023 May; 143 (5): s140Proceeding / Abstract / Poster818 Multi-condition TWAS for inflammatory skin disorders highlights roles of genetic signals in cytokine-stimulated keratinocytes
DOI:10.1016/j.jid.2023.03.828
