Li-Jyun Syu
Assistant Research Scientist
Dermatology
Dermatology
3431 Rogel Cancer Center, 1500 East Medical Center Drive
Ann Arbor, MI 48109
[email protected]

Available to mentor
Li-Jyun Syu
Assistant Research Scientist
  • Qualifications
  • Research Overview
  • Recent Publications
    • Qualifications
    • Postdoctoral Research Fellow
      University of Michigan Medical School, Dermatology, 2009
    • Postdoctoral Research Fellow
      Warner-Lambert Company (Pfizer), Parke-Davis, Signal Transduction and Cell Biology, 2000
    • Postdoctoral Research Fellow
      University of Michigan–Ann Arbor, Biological Chemistry, 1996
    • Ph.D.
      Michigan State University, Department of Microbiology and Public Health, 1994
    • Bachelor of Science
      National Taiwan University, Department of Agricultural Chemistry, 1985
    Research Overview

    My recent interest has aimed at understanding the molecular basis of human polyomaviruses-associated hair follicle disorder (Trichodysplasia Spinulosa) and Merkel cell carcinoma. Past experience includes studies of Hedgehog (Hh) and Wnt signaling in development, regeneration, and neoplastic transformation of skin and other organs.

    Recent Publications See All Publications
    • Proceeding / Abstract / Poster
      LB1665 CRISPR/Cas9-mediated genome editing in postnatal epidermis drives squamous tumor development
      Syu L, Mishra S, Wu R, Wilbert D, Ryan R, Cho K, Dlugosz A. Journal of Investigative Dermatology, 2023 Sep; 143 (9): b8 DOI:10.1016/j.jid.2023.06.036
    • Journal Article
      ISIDLB1665 - CRISPR/Cas9-mediated genome editing in postnatal epidermis drives squamous tumor development
      Syu L-J. DOI:10.26226/m.6437c11f7d8705001200b956
    • Proceeding / Abstract / Poster
      1282 Basal cell carcinoma pigmentation is associated with melanocyte proliferation and expression of the melanocyte mitogens endothelin 1 and 2 by tumor cells
      Pedersen EA, Grachtchouk MA, Verhaegen ME, Syu L, Harms PW, Gharaee-Kermani M, Ma F, Gudjonsson J, Ito M, Dlugosz A. Journal of Investigative Dermatology, 2023 May; 143 (5): s220 DOI:10.1016/j.jid.2023.03.1296
    • Proceeding / Abstract / Poster
      LB1019 The early region of trichodysplasia spinulosa polyomavirus drives proliferation, altered differentiation, and ectopic expression of hair follicle differentiation markers in interfollicular tail epidermis
      Syu L, Wilbert D, van der Meijden E, Feltkamp M, Dlugosz AA. Journal of Investigative Dermatology, 2022 Aug; 142 (8): b33 DOI:10.1016/j.jid.2022.05.1047
    • Journal Article
      Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.
      Verhaegen ME, Harms PW, Van Goor JJ, Arche J, Patrick MT, Wilbert D, Zabawa H, Grachtchouk M, Liu C-J, Hu K, Kelly MC, Chen P, Saunders TL, Weidinger S, Syu L-J, Runge JS, Gudjonsson JE, Wong SY, Brownell I, Cieslik M, Udager AM, Chinnaiyan AM, Tsoi LC, Dlugosz AA. J Clin Invest, 2022 Apr 1; 132 (7): DOI:10.1172/JCI152069
      PMID: 35143422
    • Journal Article
      Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles.
      Grunberg N, Pevsner-Fischer M, Goshen-Lago T, Diment J, Stein Y, Lavon H, Mayer S, Levi-Galibov O, Friedman G, Ofir-Birin Y, Syu L-J, Migliore C, Shimoni E, Stemmer SM, Brenner B, Dlugosz AA, Lyden D, Regev-Rudzki N, Ben-Aharon I, Scherz-Shouval R. Cancer Res, 2021 Apr 1; 81 (7): 1639 - 1653. DOI:10.1158/0008-5472.CAN-20-2756
      PMID: 33547159
    • Journal Article
      Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer.
      Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu L, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, Irizarry-Negron V, Halbrook CJ, Franks NE, Hoffman MT, Brown K, Carpenter ES, Nwosu ZC, Johnson C, Lima F, Anderson MA, Park Y, Crawford HC, Lyssiotis CA, Frankel TL, Rao A, Bednar F, Dlugosz AA, Preall JB, Tuveson DA, Allen BL, Pasca di Magliano M. Clin Cancer Res, 2021 Apr 1; 27 (7): 2023 - 2037. DOI:10.1158/1078-0432.CCR-20-3715
      PMID: 33495315
    • Journal Article
      Aim2-mediated/IFN-β-independent regulation of gastric metaplastic lesions via CD8+ T cells.
      El-Zaatari M, Bishu S, Zhang M, Grasberger H, Hou G, Haley H, Humphries B, Syu L-J, Dlugosz AA, Luker K, Luker GD, Eaton K, Kamada N, Cascalho M, Kao JY. JCI Insight, 2020 Mar 12; 5 (5): DOI:10.1172/jci.insight.94035
      PMID: 32053518